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• W1882160216 abstract "Abstract After developing in the thymus, recent thymic emigrants (RTEs) enter the lymphoid periphery and undergo a maturation process as they transition into the mature naive (MN) T cell compartment. This maturation presumably shapes RTEs into a pool of T cells best fit to function robustly in the periphery without causing autoimmunity; however, the mechanism and consequences of this maturation process remain unknown. Using a transgenic mouse system that specifically labels RTEs, we tested the influence of MHC molecules, key drivers of intrathymic T cell selection and naive peripheral T cell homeostasis, in shaping the RTE pool in the lymphoid periphery. We found that the TCRs expressed by RTEs are skewed to longer CDR3 regions compared with those of MN T cells, suggesting that MHC does streamline the TCR repertoire of T cells as they transition from the RTE to the MN T cell stage. This conclusion is borne out in studies in which the representation of individual TCRs was followed as a function of time since thymic egress. Surprisingly, we found that MHC is dispensable for the phenotypic and functional maturation of RTEs." @default.
• W1882160216 created "2016-06-24" @default.
• W1882160216 creator A5036928658 @default.
• W1882160216 creator A5088518192 @default.
• W1882160216 date "2009-12-01" @default.
• W1882160216 modified "2023-10-02" @default.
• W1882160216 title "MHC Drives TCR Repertoire Shaping, but not Maturation, in Recent Thymic Emigrants" @default.
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• W1882160216 doi "https://doi.org/10.4049/jimmunol.0902313" @default.
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• W1882160216 hasPublicationYear "2009" @default.
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