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• W1882160969 abstract "Sn2 lipase labile phospholipid prodrugs in conjunction with contact‐facilitated drug delivery offer an important advancement in Nanomedicine. Many drugs incorporated into nanosystems, targeted or not, are substantially lost during circulation to the target. However, favorably altering the pharmacokinetics and volume of distribution of systemic drug delivery can offer greater efficacy with lower toxicity, leading to new prolonged‐release nanoexcipients. However, the concept of achieving Paul Erhlich's inspired vision of a ‘magic bullet’ to treat disease has been largely unrealized due to unstable nanomedicines, nanosystems achieving low drug delivery to target cells, poor intracellular bioavailability of endocytosed nanoparticle payloads, and the substantial biological barriers of extravascular particle penetration into pathological sites. As shown here, Sn2 phospholipid prodrugs in conjunction with contact‐facilitated drug delivery prevent premature drug diffusional loss during circulation and increase target cell bioavailability. The Sn2 phospholipid prodrug approach applies equally well for vascular constrained lipid‐encapsulated particles and micelles the size of proteins that penetrate through naturally fenestrated endothelium in the bone marrow or thin‐walled venules of an inflamed microcirculation. At one time Nanomedicine was considered a ‘Grail Quest’ by its loyal opposition and even many in the field adsorbing the pains of a long‐learning curve about human biology and particles. However, Nanomedicine with innovations like Sn2 phospholipid prodrugs has finally made ‘made the turn’ toward meaningful translational success. WIREs Nanomed Nanobiotechnol 2015, 8:85–106. doi: 10.1002/wnan.1355 This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Lipid-Based Structures" @default.
• W1882160969 created "2016-06-24" @default.
• W1882160969 creator A5021845859 @default.
• W1882160969 creator A5042700347 @default.
• W1882160969 creator A5046404222 @default.
• W1882160969 creator A5049848615 @default.
• W1882160969 creator A5055819205 @default.
• W1882160969 creator A5063285199 @default.
• W1882160969 date "2015-08-21" @default.
• W1882160969 modified "2023-10-15" @default.
• W1882160969 title "Contact‐facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery" @default.
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