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• W1882201941 abstract "A systematic study was conducted on round spermatids (ROS) injection (ROSI) using the goat model. After ROSI, the oocytes were treated or not with ionomycin (ROSI+I and ROSI−I, respectively) and compared with intracytoplasmic sperm injection (ICSI). After ROSI−I, most oocytes were arrested with premature chromatin condensation and few oocytes formed pronuclei. In contrast, most oocytes formed pronuclei after ROSI+I. Some ROS were observed to form asters that organized a dense microtubule network after ROSI+I, but after ROSI−I, no ROS asters were observed. Whereas most of the oocytes showed Ca2+ rises and a significant decline in maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) activities after ROSI+I, no such changes were observed after ROSI−I. Due to the lack of Ca2+ oscillations after ROSI−I, oocytes were injected with more ROS. Interestingly, different from the results observed in a single ROS injection, injection with four ROS effectively activated oocytes by inducing typical Ca2+ oscillations. Whereas ROSI+I oocytes and ICSI oocytes both showed extensive microtubule networks, no such a network was observed in parthenogenetic oocytes. Together, the results suggest that goat ROS is not able to trigger intracellular Ca2+ rises and thus to inhibit MPF and MAPK activities, but artificial activation improved fertilization and development of ROSI goat oocytes. Goat ROS can organize functional microtubular asters in activated oocytes. A ROS-derived factor(s) may be essential for organization of a functional microtubule network to unite pronuclei. Goat centrosome is of paternal origin because both ROS and sperm asters organized an extensive microtubule network after intra-oocyte injection." @default.
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• W1882201941 date "2012-10-01" @default.
• W1882201941 modified "2023-09-27" @default.
• W1882201941 title "Effects of Activation on Functional Aster Formation, Microtubule Assembly, and Blastocyst Development of Goat Oocytes Injected with Round Spermatids" @default.
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• W1882201941 doi "https://doi.org/10.1089/cell.2012.0029" @default.
• W1882201941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3459009" @default.
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