Matches in SemOpenAlex for { <https://semopenalex.org/work/W188255156> ?p ?o ?g. }
- W188255156 endingPage "280" @default.
- W188255156 startingPage "269" @default.
- W188255156 abstract "The past two years have witnessed the rapid merging of the HIV and chemokine-receptor fields, no doubt to the surprise of all involved (reviewed in refs. 1–4). It became evident soon after the discovery of CD4 as the primary receptor for HIV-1 that one or more additional cell-surface molecules (coreceptors) were required in conjunction with CD4 to support entry of the virus into cells (5). The realization that HIV-1 strains exhibit distinct cellular tropisms indicated that strain-specific coreceptors might exist. Over the ensuing decade, numerous candidate coreceptors were proposed, none of which stood the test of time. Finally, the first significant step towards solving this problem came in late 1995 when Cocchi, Lusso, and co-workers identified the CC chemokines RANTES, MIP-1α, and MIP-1β as factors secreted by CD8+ T cells that were able to suppress some HIV-1 strains (6). However, the true significance of this finding was not fully apparent until Berger and colleagues independently identified the first bona fide HIV-1 coreceptor, termed fusin (7). This was an orphan seven transmembrane domain receptor first cloned in 1993 (8). Of significance for understanding HIV-1 tropism was that, whereas fusin was clearly shown to serve as a coreceptor for T-tropic virus strains, expression of fusin with CD4 did not allow entry of the more common M-tropic viruses (7). However, the homology of fusin to the chemokine receptor family indicated that a receptor competent to bind RANTES, MIP1-α, and MIP1-β would be an excellent candidate for the M-tropic virus coreceptor. The publication of a receptor with this binding profile, termed CCR5 (9) enabled five groups to simultaneously identify this molecule as the major HIV-1 coreceptor (10–14). Confirmation that CCR5 is the major HIV-1 coreceptor in vivo came from the finding that individuals who lack CCR5 because of an inherited polymorphism (D32-ccr5) are highly resistant to virus infection, and that individuals who have only one copy of this allele exhibit a delayed progression to AIDS (15–17). Subsequently, fusin was shown to be the receptor for the CXC chemokine SDF-1 and, as a result, was renamed CXCR4 (18,19)." @default.
- W188255156 created "2016-06-24" @default.
- W188255156 creator A5010176130 @default.
- W188255156 creator A5022966532 @default.
- W188255156 date "1999-01-01" @default.
- W188255156 modified "2023-09-24" @default.
- W188255156 title "HIV-1 Coreceptors and Viral Tropism" @default.
- W188255156 cites W1493470785 @default.
- W188255156 cites W1587286994 @default.
- W188255156 cites W1594946825 @default.
- W188255156 cites W1623426438 @default.
- W188255156 cites W1642524132 @default.
- W188255156 cites W1657819831 @default.
- W188255156 cites W1679721892 @default.
- W188255156 cites W1723922714 @default.
- W188255156 cites W1731073298 @default.
- W188255156 cites W1739595091 @default.
- W188255156 cites W1840516913 @default.
- W188255156 cites W1848605842 @default.
- W188255156 cites W1881691580 @default.
- W188255156 cites W1946734657 @default.
- W188255156 cites W1963984954 @default.
- W188255156 cites W1965019797 @default.
- W188255156 cites W1969190686 @default.
- W188255156 cites W1971057735 @default.
- W188255156 cites W1971777539 @default.
- W188255156 cites W1972056955 @default.
- W188255156 cites W1981440980 @default.
- W188255156 cites W1981644527 @default.
- W188255156 cites W1984811742 @default.
- W188255156 cites W1989035987 @default.
- W188255156 cites W1989701896 @default.
- W188255156 cites W1993591984 @default.
- W188255156 cites W1996183144 @default.
- W188255156 cites W2007021820 @default.
- W188255156 cites W2008130406 @default.
- W188255156 cites W2009324334 @default.
- W188255156 cites W2010068219 @default.
- W188255156 cites W2011103103 @default.
- W188255156 cites W2017551575 @default.
- W188255156 cites W2026330341 @default.
- W188255156 cites W2026444780 @default.
- W188255156 cites W2028309086 @default.
- W188255156 cites W2034430377 @default.
- W188255156 cites W2037793240 @default.
- W188255156 cites W2042578530 @default.
- W188255156 cites W2043482309 @default.
- W188255156 cites W2051377225 @default.
- W188255156 cites W2052392655 @default.
- W188255156 cites W2053521361 @default.
- W188255156 cites W2062148688 @default.
- W188255156 cites W2067964854 @default.
- W188255156 cites W2074888333 @default.
- W188255156 cites W2075416959 @default.
- W188255156 cites W2078778857 @default.
- W188255156 cites W2079080976 @default.
- W188255156 cites W2087343656 @default.
- W188255156 cites W2090630729 @default.
- W188255156 cites W2092788945 @default.
- W188255156 cites W2098787529 @default.
- W188255156 cites W2102559570 @default.
- W188255156 cites W2103615498 @default.
- W188255156 cites W2106513047 @default.
- W188255156 cites W2108256128 @default.
- W188255156 cites W2114279162 @default.
- W188255156 cites W2114668630 @default.
- W188255156 cites W2115042572 @default.
- W188255156 cites W2116296362 @default.
- W188255156 cites W2116444325 @default.
- W188255156 cites W2117394497 @default.
- W188255156 cites W2121117011 @default.
- W188255156 cites W2124846613 @default.
- W188255156 cites W2126255146 @default.
- W188255156 cites W2129875326 @default.
- W188255156 cites W2129969146 @default.
- W188255156 cites W2131376910 @default.
- W188255156 cites W2131997843 @default.
- W188255156 cites W2132142355 @default.
- W188255156 cites W2132870230 @default.
- W188255156 cites W2137162710 @default.
- W188255156 cites W2141003640 @default.
- W188255156 cites W2142655367 @default.
- W188255156 cites W2143584481 @default.
- W188255156 cites W2143663670 @default.
- W188255156 cites W2147351662 @default.
- W188255156 cites W2147907754 @default.
- W188255156 cites W2150898533 @default.
- W188255156 cites W2152003330 @default.
- W188255156 cites W2154205595 @default.
- W188255156 cites W2156694786 @default.
- W188255156 cites W2162772698 @default.
- W188255156 cites W2163611230 @default.
- W188255156 cites W2164371532 @default.
- W188255156 cites W2164592489 @default.
- W188255156 cites W2166240517 @default.
- W188255156 cites W2170119258 @default.
- W188255156 cites W2171944465 @default.
- W188255156 cites W2275351935 @default.