FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1882552011> ?p ?o ?g. }

• W1882552011 abstract "Malaria remains a major public health concern for billions of people worldwide. Achieving the ambitious goal of malaria eradication requires co-ordination of control strategies dealing with a range of parasite, vector, human, social and environmental factors. Availability of effective antimalarial treatment is a key component in malaria control. However the number of drugs available is limited and drug resistance, particularly in Plasmodium falciparum, has now been reported for all currently available antimalarials. Mathematical models provide the opportunity to explore key features underlying antimalarial drug action, effectiveness and resistance. They further allow investigation into questions that cannot otherwise be easily addressed, either because they are too expensive, unethical or logistically too complex. This thesis aims to develop pharmacological models to investigate antimalarial drug treatment.In Chapter 2 we develop a pharmacokinetic-pharmacodynamic (PK/PD) model of antimalarial drug treatment (calibrated using published data) and use it to investigate the efficacy of artemisinin combination therapies (ACTs).Chapter 3 addresses two assumptions built into the methodology that limit the models future application. The model now allows for (i) time lags and drug concentration profiles for drugs absorbed across the gut wall and, if necessary, converted to another active form (ii) multiple drugs within a treatment regimen (iii) differing modes of drug action in combinations (iv) modelling drugs converted to an active metabolite with similar modes of action.In Chapter 4 we extend the methodology to allow for i) the presence of more than one clone when treatment begins (ii) the acquisition of new clones during treatment follow-up (iii) the tracking of individual clones using molecular markers. We then use these extensions to simulate clinical trial data to determine the best methods of analysis.Chapter 5 details how the drug action components of the extended PK/PD model were incorporated into OpenMalaria; a mathematical model of malaria epidemiology allowing investigation of the effects of various intervention strategies including malaria vaccines, vector control strategies and antimalarial drug treatment.In Chapter 6 we investigate the ability of clinical trials to accurately estimate (WoS) using the extended PK/PD model. Windows of selection (WoS) are often used to quantify the genetic process whereby parasites evolve increasing tolerance to antimalarial drugs.We noted a conspicuous lack of comprehensive, good-quality PK datasets currently available in the literature. Despite this, the models produced results highly consistent with field data. They were applied to investigate the potential implications of drug resistance and to make predications about the future effectiveness of antimalarials. We emphasise the value of mathematical models by simulating ‘field data’ to assess the best methods of analysing clinical trials and to investigate the predictive ability of WoS. While we do not suggest models can replace the information gained in clinical trials, this work does demonstrate the importance of mathematical models capable of generating results consistent with field data." @default.
• W1882552011 created "2016-06-24" @default.
• W1882552011 creator A5078265839 @default.
• W1882552011 date "2013-07-01" @default.
• W1882552011 modified "2023-09-27" @default.
• W1882552011 title "Pharmacological modelling to investigate antimalarial drug treatment" @default.
• W1882552011 hasPublicationYear "2013" @default.
• W1882552011 type Work @default.
• W1882552011 sameAs 1882552011 @default.
• W1882552011 citedByCount "0" @default.
• W1882552011 crossrefType "dissertation" @default.
• W1882552011 hasAuthorship W1882552011A5078265839 @default.
• W1882552011 hasConcept C112930515 @default.
• W1882552011 hasConcept C114851261 @default.
• W1882552011 hasConcept C203014093 @default.
• W1882552011 hasConcept C2776120307 @default.
• W1882552011 hasConcept C2778048844 @default.
• W1882552011 hasConcept C2778371730 @default.
• W1882552011 hasConcept C2780035454 @default.
• W1882552011 hasConcept C70721500 @default.
• W1882552011 hasConcept C71924100 @default.
• W1882552011 hasConcept C86803240 @default.
• W1882552011 hasConcept C89423630 @default.
• W1882552011 hasConcept C98274493 @default.
• W1882552011 hasConceptScore W1882552011C112930515 @default.
• W1882552011 hasConceptScore W1882552011C114851261 @default.
• W1882552011 hasConceptScore W1882552011C203014093 @default.
• W1882552011 hasConceptScore W1882552011C2776120307 @default.
• W1882552011 hasConceptScore W1882552011C2778048844 @default.
• W1882552011 hasConceptScore W1882552011C2778371730 @default.
• W1882552011 hasConceptScore W1882552011C2780035454 @default.
• W1882552011 hasConceptScore W1882552011C70721500 @default.
• W1882552011 hasConceptScore W1882552011C71924100 @default.
• W1882552011 hasConceptScore W1882552011C86803240 @default.
• W1882552011 hasConceptScore W1882552011C89423630 @default.
• W1882552011 hasConceptScore W1882552011C98274493 @default.
• W1882552011 hasLocation W18825520111 @default.
• W1882552011 hasOpenAccess W1882552011 @default.
• W1882552011 hasPrimaryLocation W18825520111 @default.
• W1882552011 hasRelatedWork W1968690857 @default.
• W1882552011 hasRelatedWork W1970647602 @default.
• W1882552011 hasRelatedWork W2010009421 @default.
• W1882552011 hasRelatedWork W2012258432 @default.
• W1882552011 hasRelatedWork W2028222118 @default.
• W1882552011 hasRelatedWork W2030942695 @default.
• W1882552011 hasRelatedWork W2032477186 @default.
• W1882552011 hasRelatedWork W2040106948 @default.
• W1882552011 hasRelatedWork W2074733420 @default.
• W1882552011 hasRelatedWork W2110377819 @default.
• W1882552011 hasRelatedWork W2121494339 @default.
• W1882552011 hasRelatedWork W2154488525 @default.
• W1882552011 hasRelatedWork W2169819398 @default.
• W1882552011 hasRelatedWork W2949698708 @default.
• W1882552011 hasRelatedWork W3082220936 @default.
• W1882552011 hasRelatedWork W3128694216 @default.
• W1882552011 hasRelatedWork W3180099097 @default.
• W1882552011 hasRelatedWork W382959330 @default.
• W1882552011 hasRelatedWork W2100464647 @default.
• W1882552011 hasRelatedWork W2181367257 @default.
• W1882552011 isParatext "false" @default.
• W1882552011 isRetracted "false" @default.
• W1882552011 magId "1882552011" @default.
• W1882552011 workType "dissertation" @default.