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- W1882568290 abstract "The bioavailability of orally administered mono- and polyglutamyl folates was examined in humans by using stable-isotope methods. [3',5'-2H2]Folic acid (d2-FA) and [3',5'-2H2]pteroylhexaglutamate (d2-PteGlu6) were prepared for oral administration and (glu-2H4)folic acid (d4-FA) was prepared for intravenous (iv) injection. In two trials, adult males (n = 1) on a folate saturation regimen (2 mg/d) were given a single 677-nmol oral dose of either d2-FA or d2-PteGlu6 in apple juice along with an iv injection of 502 nmol d4-FA as a control. Urine was collected for 48 h and the isotope labeling of urinary folates determined by mass spectrometry. The excretion ratio of urinary folates (% of d2-folate dose/% of d4-folate dose) resulting from oral d2-FA and iv d4-FA was 1.45 ± 0.10 (x ± SEM) whereas the ratio for oral d2-PteGlu6 and iv d4-FA was 0.67 ± 0.04. These results indicate that the d2-PteGlu6 is available to humans as a source of folate although its bioavailability is substantially less than that of d2-FA under these conditions." @default.
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- W1882568290 date "1991-03-01" @default.
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- W1882568290 title "Relative bioavailability of deuterium-labeled monoglutamyl and hexaglutamyl folates in human subjects" @default.
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- W1882568290 doi "https://doi.org/10.1093/ajcn/53.3.736" @default.
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