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• W1882770623 abstract "Dysfunctional interactions of amyloid-β (Aβ) with Zn and Cu ions are proved to be related to the etiology of Alzheimer's disease (AD). Disruption of these metal-Aβ interactions using metal chelators holds considerable promise as a therapeutic strategy to combat this incurable disease. Herein, we report that two cyclam derivatives (L1 and L2) are capable of modulating Zn(2+)/Cu(2+)-mediated Aβ40 aggregation, reactive oxygen species (ROS) production, and neurotoxicity. These chelators were found to inhibit the metal-induced Aβ40 aggregation, dissociate metal-Aβ40 aggregates and restore the metal-induced β-sheet structure of Aβ40 to its random coil conformation, as observed by BCA protein assay, thioflavin T fluorescence and circular dichroism spectroscopy. Moreover, preliminary investigation of SH-SY5Y cells indicates that L1 and L2 can diminish the neurotoxicity of metal-Aβ40 species, control metal-Aβ40-triggered ROS production and protect cells against apoptosis. These observations warrant the further investigations of L1 and L2 as potential anti-AD agents." @default.
• W1882770623 created "2016-06-24" @default.
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• W1882770623 date "2015-01-01" @default.
• W1882770623 modified "2023-09-28" @default.
• W1882770623 title "Two macrocyclic polyamines as modulators of metal-mediated Aβ₄₀aggregation" @default.
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• W1882770623 doi "https://doi.org/10.1039/c5ib00064e" @default.
• W1882770623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25968625" @default.
• W1882770623 hasPublicationYear "2015" @default.
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