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• W1882787745 abstract "Background: Depression is a major public health problem among youth, currently estimated to affect as many as 9% of US children and adolescents. The recognition that both genes (nature) and environments (nurture) are important for understanding the etiology of depression has led to a rapid growth in research exploring gene–environment interactions (GxE). However, there has been no systematic review of GxE in youth depression to date. Methods: The goal of this article was to systematically review evidence on the contribution of GxE to the risk of child and adolescent depression. Through a search of PubMed and PsycINFO databases to 1 April 2010, we identified 20 candidate gene–environment interaction studies focused on depression in youth (up to age 26) and compared each study in terms of the following characteristics: research design and sample studied; measure of depression and environment used; genes explored; and GxE findings in relation to these factors. Results: In total, 80% of studies (n = 16) found at least one significant GxE association. However, there was wide variation in methods and analyses adopted across studies, especially with respect to environmental measures used and tests conducted to estimate GxE. This heterogeneity made it difficult to compare findings and evaluate the strength of the evidence for GxE. Conclusions: The existing body of GxE research on depression in youth contains studies that are conceptually and methodologically quite different, which contributes to mixed findings and makes it difficult to assess the current state of the evidence. To decrease this heterogeneity, we offer 20 recommendations that are focused on: (a) reporting GxE research; (b) testing and reporting GxE effects; (c) conceptualizing, measuring and analyzing depression; (d) conceptualizing, measuring and analyzing environment; (e) increasing power to test for GxE; and (f) improving the quality of genetic data used. Although targeted to GxE research on depression, these recommendations can be adopted by GxE researchers focusing on other mental health outcomes." @default.
• W1882787745 created "2016-06-24" @default.
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• W1882787745 date "2011-09-29" @default.
• W1882787745 modified "2023-10-16" @default.
• W1882787745 title "Research Review: Gene-environment interaction research in youth depression - a systematic review with recommendations for future research" @default.
• W1882787745 cites W1849301062 @default.
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• W1882787745 cites W1968491720 @default.
• W1882787745 cites W1976439883 @default.
• W1882787745 cites W1980523782 @default.
• W1882787745 cites W1980533762 @default.
• W1882787745 cites W1981819352 @default.
• W1882787745 cites W1984230889 @default.
• W1882787745 cites W1987375729 @default.
• W1882787745 cites W1988176578 @default.
• W1882787745 cites W1988981053 @default.
• W1882787745 cites W1989784453 @default.
• W1882787745 cites W1990914822 @default.
• W1882787745 cites W1993333521 @default.
• W1882787745 cites W1994286942 @default.
• W1882787745 cites W1997878885 @default.
• W1882787745 cites W2000701222 @default.
• W1882787745 cites W2001028204 @default.
• W1882787745 cites W2004435166 @default.
• W1882787745 cites W2015260068 @default.
• W1882787745 cites W2021622240 @default.
• W1882787745 cites W2025006974 @default.
• W1882787745 cites W2030499937 @default.
• W1882787745 cites W2031415599 @default.
• W1882787745 cites W2032236081 @default.
• W1882787745 cites W2034004647 @default.
• W1882787745 cites W2034325147 @default.
• W1882787745 cites W2038714501 @default.
• W1882787745 cites W2042170262 @default.
• W1882787745 cites W2047303361 @default.
• W1882787745 cites W2055472142 @default.
• W1882787745 cites W2058463674 @default.
• W1882787745 cites W2069799601 @default.
• W1882787745 cites W2076358520 @default.
• W1882787745 cites W2080229119 @default.
• W1882787745 cites W2083020792 @default.
• W1882787745 cites W2089117003 @default.
• W1882787745 cites W2089259348 @default.
• W1882787745 cites W2100230238 @default.
• W1882787745 cites W2102507149 @default.
• W1882787745 cites W2105874139 @default.
• W1882787745 cites W2114906335 @default.
• W1882787745 cites W2115871268 @default.
• W1882787745 cites W2117527509 @default.
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• W1882787745 cites W2138962612 @default.
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• W1882787745 cites W2149375666 @default.
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• W1882787745 cites W2500940424 @default.
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• W1882787745 doi "https://doi.org/10.1111/j.1469-7610.2011.02466.x" @default.
• W1882787745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3202044" @default.
• W1882787745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21954964" @default.
• W1882787745 hasPublicationYear "2011" @default.
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