FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W188281310> ?p ?o ?g. }

• W188281310 endingPage "64" @default.
• W188281310 startingPage "1453" @default.
• W188281310 abstract "This study aimed to understand gradual biological variations during gastric tumorigenesis, and to identify the candidate genes that are involved in tumor progression and metastasis.cDNA microarray data were obtained from 10 pair of cancerous and normal adjacent tissue from gastric adenocarcinoma patients. The samples were divided in primary and advanced gastric adenocarcinoma with lymph node metastasis. Validation of the microarray data was accomplished by quantitative RT-PCR on additional 41 samples. The significantly modified genes were grouped in clusters according to their functional annotation, and comparison was done regarding molecular mechanisms involved tumor progression.A total of 136 genes were up-regulated and 96 genes were down-regulated by at least fourfold in tumor tissue. The analysis of gene clusters revealed a complex remodelling of normal gastric epithelium morphology and function associated with the tumorigenesis and metastasis. A large number of proteases are being overexpressed, together with keratins, genes associated with morphogenesis and anti-apoptosis. Between the most significant down-regulated genes, there were genes involved in gastric motility and synthesis and genes related to metabolic and pro-apoptotic processes. We also report, the identification of seven genes, significant up-regulated, that seem to be associated with tumor progression: KRT17, COL10A2, KIAA1199, SPP1, IL11, S100A2, and MMP3.Our cDNA microarray study identified several genes that appeared to meet the criteria of a good biomarker, and may therefore be especially useful for the development of diagnostic tools, for the early detection, or for the prediction of tumor progression." @default.
• W188281310 created "2016-06-24" @default.
• W188281310 creator A5003802884 @default.
• W188281310 creator A5023690844 @default.
• W188281310 creator A5035535828 @default.
• W188281310 creator A5040302502 @default.
• W188281310 creator A5046338040 @default.
• W188281310 creator A5058340511 @default.
• W188281310 creator A5059446527 @default.
• W188281310 creator A5082319360 @default.
• W188281310 creator A5089385739 @default.
• W188281310 date "2011-03-30" @default.
• W188281310 modified "2023-10-18" @default.
• W188281310 title "Identification of potential biomarkers for early and advanced gastric adenocarcinoma detection." @default.
• W188281310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21443102" @default.
• W188281310 hasPublicationYear "2011" @default.
• W188281310 type Work @default.
• W188281310 sameAs 188281310 @default.
• W188281310 citedByCount "20" @default.
• W188281310 countsByYear W1882813102012 @default.
• W188281310 countsByYear W1882813102014 @default.
• W188281310 countsByYear W1882813102015 @default.
• W188281310 countsByYear W1882813102016 @default.
• W188281310 countsByYear W1882813102017 @default.
• W188281310 countsByYear W1882813102018 @default.
• W188281310 countsByYear W1882813102019 @default.
• W188281310 countsByYear W1882813102020 @default.
• W188281310 countsByYear W1882813102021 @default.
• W188281310 countsByYear W1882813102022 @default.
• W188281310 countsByYear W1882813102023 @default.
• W188281310 crossrefType "journal-article" @default.
• W188281310 hasAuthorship W188281310A5003802884 @default.
• W188281310 hasAuthorship W188281310A5023690844 @default.
• W188281310 hasAuthorship W188281310A5035535828 @default.
• W188281310 hasAuthorship W188281310A5040302502 @default.
• W188281310 hasAuthorship W188281310A5046338040 @default.
• W188281310 hasAuthorship W188281310A5058340511 @default.
• W188281310 hasAuthorship W188281310A5059446527 @default.
• W188281310 hasAuthorship W188281310A5082319360 @default.
• W188281310 hasAuthorship W188281310A5089385739 @default.
• W188281310 hasConcept C104317684 @default.
• W188281310 hasConcept C121608353 @default.
• W188281310 hasConcept C142724271 @default.
• W188281310 hasConcept C150194340 @default.
• W188281310 hasConcept C186836561 @default.
• W188281310 hasConcept C2779013556 @default.
• W188281310 hasConcept C2779256057 @default.
• W188281310 hasConcept C2781182431 @default.
• W188281310 hasConcept C2781197716 @default.
• W188281310 hasConcept C502942594 @default.
• W188281310 hasConcept C54355233 @default.
• W188281310 hasConcept C555283112 @default.
• W188281310 hasConcept C71924100 @default.
• W188281310 hasConcept C8415881 @default.
• W188281310 hasConcept C86803240 @default.
• W188281310 hasConceptScore W188281310C104317684 @default.
• W188281310 hasConceptScore W188281310C121608353 @default.
• W188281310 hasConceptScore W188281310C142724271 @default.
• W188281310 hasConceptScore W188281310C150194340 @default.
• W188281310 hasConceptScore W188281310C186836561 @default.
• W188281310 hasConceptScore W188281310C2779013556 @default.
• W188281310 hasConceptScore W188281310C2779256057 @default.
• W188281310 hasConceptScore W188281310C2781182431 @default.
• W188281310 hasConceptScore W188281310C2781197716 @default.
• W188281310 hasConceptScore W188281310C502942594 @default.
• W188281310 hasConceptScore W188281310C54355233 @default.
• W188281310 hasConceptScore W188281310C555283112 @default.
• W188281310 hasConceptScore W188281310C71924100 @default.
• W188281310 hasConceptScore W188281310C8415881 @default.
• W188281310 hasConceptScore W188281310C86803240 @default.
• W188281310 hasIssue "104" @default.
• W188281310 hasLocation W1882813101 @default.
• W188281310 hasOpenAccess W188281310 @default.
• W188281310 hasPrimaryLocation W1882813101 @default.
• W188281310 hasRelatedWork W1512989968 @default.
• W188281310 hasRelatedWork W1984181658 @default.
• W188281310 hasRelatedWork W1989262480 @default.
• W188281310 hasRelatedWork W2023950003 @default.
• W188281310 hasRelatedWork W2049397238 @default.
• W188281310 hasRelatedWork W2075500360 @default.
• W188281310 hasRelatedWork W2106787323 @default.
• W188281310 hasRelatedWork W2116859091 @default.
• W188281310 hasRelatedWork W2118258530 @default.
• W188281310 hasRelatedWork W2126547130 @default.
• W188281310 hasRelatedWork W2139362027 @default.
• W188281310 hasRelatedWork W2164645711 @default.
• W188281310 hasRelatedWork W2184885683 @default.
• W188281310 hasRelatedWork W2187832082 @default.
• W188281310 hasRelatedWork W2338576041 @default.
• W188281310 hasRelatedWork W2889646458 @default.
• W188281310 hasRelatedWork W2991505125 @default.
• W188281310 hasRelatedWork W2996268728 @default.
• W188281310 hasRelatedWork W3142011009 @default.
• W188281310 hasRelatedWork W63977065 @default.
• W188281310 hasVolume "57" @default.
• W188281310 isParatext "false" @default.
• W188281310 isRetracted "false" @default.
• W188281310 magId "188281310" @default.

• next