FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1882868061> ?p ?o ?g. }

• W1882868061 endingPage "5551" @default.
• W1882868061 startingPage "5533" @default.
• W1882868061 abstract "Astaxanthin (Asta), a photo-protective red pigment of the carotenoid family, is known for its multiple beneficial properties. In this study, the effects of Asta on isolated human sperm were evaluated. Capacitation involves a series of transformations to let sperm acquire the correct features for potential oocyte fertilization, including the generation of a controlled amount of reactive oxygen species (ROS), cholesterol depletion of the sperm outer membrane, and protein tyrosine phosphorylation (Tyr-P) process in the head region. Volunteers, with normal spermiogram values, were divided in two separate groups on the basis of their ability to generate the correct content of endogenous ROS. Both patient group (PG) and control group (CG) were analysed for Tyr-phosphorylation (Tyr-P) pattern and percentages of acrosome-reacted cells (ARC) and non-viable cells (NVC), in the presence or absence of Asta. In addition, the involvement of ROS on membrane reorganization and the presence of Lyn, a Src family kinase associated with lipid rafts, were investigated. Results show that Lyn is present in the membranes of human sperm, mainly confined in midpiece in resting conditions. Following capacitation, Lyn translocated to the head concomitantly with raft relocation, thus allowing the Tyr-P of head proteins. Asta succeeded to trigger Lyn translocation in PG sperm thus bypassing the impaired ROS-related mechanism for rafts and Lyn translocation. In this study, we showed an interdependence between ROS generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction (AR). Asta, by ameliorating PG sperm functioning, may be utilised to decrease male idiopathic infertility." @default.
• W1882868061 created "2016-06-24" @default.
• W1882868061 creator A5014160256 @default.
• W1882868061 creator A5018555251 @default.
• W1882868061 creator A5028089892 @default.
• W1882868061 creator A5031326606 @default.
• W1882868061 creator A5042047964 @default.
• W1882868061 creator A5043635078 @default.
• W1882868061 creator A5049358228 @default.
• W1882868061 creator A5055546265 @default.
• W1882868061 creator A5070687875 @default.
• W1882868061 creator A5077538519 @default.
• W1882868061 creator A5083575743 @default.
• W1882868061 date "2015-08-25" @default.
• W1882868061 modified "2023-10-13" @default.
• W1882868061 title "Astaxanthin Improves Human Sperm Capacitation by Inducing Lyn Displacement and Activation" @default.
• W1882868061 cites W1500821773 @default.
• W1882868061 cites W1564861448 @default.
• W1882868061 cites W1868238307 @default.
• W1882868061 cites W1893995222 @default.
• W1882868061 cites W1922120593 @default.
• W1882868061 cites W1969344801 @default.
• W1882868061 cites W1982539217 @default.
• W1882868061 cites W1985854006 @default.
• W1882868061 cites W1999817659 @default.
• W1882868061 cites W2003209634 @default.
• W1882868061 cites W2008385412 @default.
• W1882868061 cites W2023621913 @default.
• W1882868061 cites W2024372419 @default.
• W1882868061 cites W2030317737 @default.
• W1882868061 cites W2053369440 @default.
• W1882868061 cites W2063651021 @default.
• W1882868061 cites W2065984876 @default.
• W1882868061 cites W2066184151 @default.
• W1882868061 cites W2070192115 @default.
• W1882868061 cites W2070987605 @default.
• W1882868061 cites W2087425286 @default.
• W1882868061 cites W2090895449 @default.
• W1882868061 cites W2101257013 @default.
• W1882868061 cites W2110789074 @default.
• W1882868061 cites W2115362831 @default.
• W1882868061 cites W2127365558 @default.
• W1882868061 cites W2130558040 @default.
• W1882868061 cites W2137306056 @default.
• W1882868061 cites W2138657902 @default.
• W1882868061 cites W2140112227 @default.
• W1882868061 cites W2142083551 @default.
• W1882868061 cites W2143812575 @default.
• W1882868061 cites W2144104681 @default.
• W1882868061 cites W2144486830 @default.
• W1882868061 cites W2150335865 @default.
• W1882868061 cites W2151907048 @default.
• W1882868061 cites W2153893753 @default.
• W1882868061 cites W2170282641 @default.
• W1882868061 cites W2244087836 @default.
• W1882868061 cites W2335077276 @default.
• W1882868061 doi "https://doi.org/10.3390/md13095533" @default.
• W1882868061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4584338" @default.
• W1882868061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26308013" @default.
• W1882868061 hasPublicationYear "2015" @default.
• W1882868061 type Work @default.
• W1882868061 sameAs 1882868061 @default.
• W1882868061 citedByCount "28" @default.
• W1882868061 countsByYear W18828680612016 @default.
• W1882868061 countsByYear W18828680612017 @default.
• W1882868061 countsByYear W18828680612018 @default.
• W1882868061 countsByYear W18828680612019 @default.
• W1882868061 countsByYear W18828680612020 @default.
• W1882868061 countsByYear W18828680612021 @default.
• W1882868061 countsByYear W18828680612022 @default.
• W1882868061 crossrefType "journal-article" @default.
• W1882868061 hasAuthorship W1882868061A5014160256 @default.
• W1882868061 hasAuthorship W1882868061A5018555251 @default.
• W1882868061 hasAuthorship W1882868061A5028089892 @default.
• W1882868061 hasAuthorship W1882868061A5031326606 @default.
• W1882868061 hasAuthorship W1882868061A5042047964 @default.
• W1882868061 hasAuthorship W1882868061A5043635078 @default.
• W1882868061 hasAuthorship W1882868061A5049358228 @default.
• W1882868061 hasAuthorship W1882868061A5055546265 @default.
• W1882868061 hasAuthorship W1882868061A5070687875 @default.
• W1882868061 hasAuthorship W1882868061A5077538519 @default.
• W1882868061 hasAuthorship W1882868061A5083575743 @default.
• W1882868061 hasBestOaLocation W18828680611 @default.
• W1882868061 hasConcept C108636557 @default.
• W1882868061 hasConcept C11960822 @default.
• W1882868061 hasConcept C16685009 @default.
• W1882868061 hasConcept C175818844 @default.
• W1882868061 hasConcept C185592680 @default.
• W1882868061 hasConcept C2777553839 @default.
• W1882868061 hasConcept C2778252442 @default.
• W1882868061 hasConcept C2779995066 @default.
• W1882868061 hasConcept C2780301668 @default.
• W1882868061 hasConcept C2781087480 @default.
• W1882868061 hasConcept C54355233 @default.
• W1882868061 hasConcept C62478195 @default.
• W1882868061 hasConcept C71924100 @default.
• W1882868061 hasConcept C79266657 @default.
• W1882868061 hasConcept C86803240 @default.

• next