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- W1882907636 abstract "To measure mitochondrial content and the expression of estrogen-related receptor-γ (ERRγ, a major inducer of mitochondrial biogenesis) in placentas from women with intrauterine growth restriction (IUGR) associated or not with pre-eclampsia (PE), relative to control placentas.Case-control study.Teaching hospital and university research laboratory.Thirty-nine placentas from women with IUGR, 8 IUGR+PE, and 30 controls.None.Mitochondrial DNA and protein content, gene and protein expression.We observed significantly lower placental mitochondrial DNA and protein contents (associated with down-regulation of ERRγ expression) in IUGR and IUGR+PE placentas, relative to control placentas. Our results also revealed that the placental mitochondrial DNA content was directly correlated with fetal weight. Moreover, we observed significantly lower peroxisome proliferator-activated receptor-γ coactivator-1α and sirtuin 1 messenger RNA expression levels in IUGR+PE placentas, relative to control placentas.The low mitochondrial DNA and protein contents observed in IUGR placentas are probably due to down-regulation of ERRγ expression. This finding suggests that ERRγ has a major role in the control of placental development." @default.
- W1882907636 created "2016-06-24" @default.
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- W1882907636 date "2015-08-01" @default.
- W1882907636 modified "2023-10-18" @default.
- W1882907636 title "Involvement of estrogen-related receptor-γ and mitochondrial content in intrauterine growth restriction and preeclampsia" @default.
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- W1882907636 doi "https://doi.org/10.1016/j.fertnstert.2015.05.005" @default.
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