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- W188292066 abstract "The regulation of cerebral blood flow (CBF) by local and peripheral mechanisms has fascinated generations of physiologists and neuroscientists. It is clear that many neurological diseases are due to altered vascular function. We will emphasize how different imaging modalities have contributed to the understanding of cerebrovascular pathophysiology. Briefly, magnetic resonance imaging (MRI) is often used to visualize regions of increased brain activity (functional magnetic resonance imaging and autoregulation studies), to measure CBF (magnetic resonance angiography) or to unveil and localize regions of blood–brain barrier (BBB) disruption (contrast MRI; measurements of endothelial tight junction integrity in normal or diseased brain). Positron-emission tomography scans can exploit brain-directed glucose transport to determine brain metabolism and to identify regions of abnormal uptake (hypo- or hypermetabolism seen in epilepsy or neoplasms). We will use the example of cerebral small vessel disease to illustrate how reduced CBF and increased BBB permeability can substantially damage brain cells to the point of causing dementia." @default.
- W188292066 created "2016-06-24" @default.
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- W188292066 date "2015-01-01" @default.
- W188292066 modified "2023-09-25" @default.
- W188292066 title "Imaging as Means to Study Cerebrovascular Pathophysiology" @default.
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- W188292066 doi "https://doi.org/10.1016/b978-0-12-397025-1.00139-1" @default.
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