FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1882922602> ?p ?o ?g. }

• W1882922602 endingPage "4384" @default.
• W1882922602 startingPage "4375" @default.
• W1882922602 abstract "Research Article1 November 1993free access Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif. M. Zanetti M. Zanetti Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author G. Filaci G. Filaci Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R.H. Lee R.H. Lee Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author P. del Guercio P. del Guercio Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author F. Rossi F. Rossi Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R. Bacchetta R. Bacchetta Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author F. Stevenson F. Stevenson Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author V. Barnaba V. Barnaba Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R. Billetta R. Billetta Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author M. Zanetti M. Zanetti Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author G. Filaci G. Filaci Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R.H. Lee R.H. Lee Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author P. del Guercio P. del Guercio Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author F. Rossi F. Rossi Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R. Bacchetta R. Bacchetta Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author F. Stevenson F. Stevenson Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author V. Barnaba V. Barnaba Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author R. Billetta R. Billetta Department of Medicine, University of California at San Diego, La Jolla 92093-0961. Search for more papers by this author Author Information M. Zanetti1, G. Filaci1, R.H. Lee1, P. Guercio1, F. Rossi1, R. Bacchetta1, F. Stevenson1, V. Barnaba1 and R. Billetta1 1Department of Medicine, University of California at San Diego, La Jolla 92093-0961. The EMBO Journal (1993)12:4375-4384https://doi.org/10.1002/j.1460-2075.1993.tb06122.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We report that an antibody engineered to express three Arg-Gly-Asp (RGD) repeats in the third complementarity-determining region of the heavy chain (antigenized antibody) efficiently inhibits the lysis of human erythroleukemia K-562 cells by natural killer (NK) cells. Synthetic peptides containing RGD did not inhibit. Inhibition was specific for the (RGD)3-containing loop and required simultaneous occupancy of the Fc receptor (CD16) on effector cells. The antigenized antibody inhibited other forms of cytotoxicity mediated by NK cells but not cytotoxicity mediated by major histocompatibility complex-restricted cytotoxic T lymphocytes (CTL). A three-dimensional model of the engineered antibody loop shows the structure and physicochemical characteristics probably required for the ligand activity. The results indicate that an RGD motif is involved in the productive interaction between NK and target cells. Moreover, they show that peptide expression in the hypervariable loops of an antibody molecule is an efficient procedure for stabilizing oligopeptides within a limited spectrum of tertiary structures. This is a new approach towards imparting ligand properties to antibody molecules and can be used to study the biological function and specificity of short peptide motifs, including those involved in cell adhesion. Previous ArticleNext Article Volume 12Issue 111 November 1993In this issue RelatedDetailsLoading ..." @default.
• W1882922602 created "2016-06-24" @default.
• W1882922602 creator A5002613530 @default.
• W1882922602 creator A5014576756 @default.
• W1882922602 creator A5018312050 @default.
• W1882922602 creator A5021869483 @default.
• W1882922602 creator A5022941983 @default.
• W1882922602 creator A5023823924 @default.
• W1882922602 creator A5047357164 @default.
• W1882922602 creator A5062279037 @default.
• W1882922602 creator A5079634281 @default.
• W1882922602 date "1993-11-01" @default.
• W1882922602 modified "2023-09-26" @default.
• W1882922602 title "Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif." @default.
• W1882922602 cites W1483915559 @default.
• W1882922602 cites W1489082035 @default.
• W1882922602 cites W1500704032 @default.
• W1882922602 cites W1507459142 @default.
• W1882922602 cites W1534784498 @default.
• W1882922602 cites W1538887755 @default.
• W1882922602 cites W1552117346 @default.
• W1882922602 cites W1552761335 @default.
• W1882922602 cites W1554699584 @default.
• W1882922602 cites W1556867369 @default.
• W1882922602 cites W1606011614 @default.
• W1882922602 cites W1607379937 @default.
• W1882922602 cites W1608855442 @default.
• W1882922602 cites W1673806489 @default.
• W1882922602 cites W1675574531 @default.
• W1882922602 cites W1964196322 @default.
• W1882922602 cites W1964264035 @default.
• W1882922602 cites W1966041739 @default.
• W1882922602 cites W1966286149 @default.
• W1882922602 cites W1968574939 @default.
• W1882922602 cites W1968682146 @default.
• W1882922602 cites W1973631782 @default.
• W1882922602 cites W1975304761 @default.
• W1882922602 cites W1978195698 @default.
• W1882922602 cites W1978947335 @default.
• W1882922602 cites W1984213068 @default.
• W1882922602 cites W1986594503 @default.
• W1882922602 cites W1987568997 @default.
• W1882922602 cites W1989237539 @default.
• W1882922602 cites W1989942521 @default.
• W1882922602 cites W1992622943 @default.
• W1882922602 cites W1993101012 @default.
• W1882922602 cites W1997639796 @default.
• W1882922602 cites W1997870466 @default.
• W1882922602 cites W2002304568 @default.
• W1882922602 cites W2004896547 @default.
• W1882922602 cites W2010320204 @default.
• W1882922602 cites W2012222242 @default.
• W1882922602 cites W2016868551 @default.
• W1882922602 cites W2017277017 @default.
• W1882922602 cites W2024488629 @default.
• W1882922602 cites W2028073474 @default.
• W1882922602 cites W2029231027 @default.
• W1882922602 cites W2036145275 @default.
• W1882922602 cites W2036376304 @default.
• W1882922602 cites W2040239455 @default.
• W1882922602 cites W2041108610 @default.
• W1882922602 cites W2050531443 @default.
• W1882922602 cites W2054726996 @default.
• W1882922602 cites W2058108669 @default.
• W1882922602 cites W2063697653 @default.
• W1882922602 cites W2067694850 @default.
• W1882922602 cites W2070471105 @default.
• W1882922602 cites W2080966713 @default.
• W1882922602 cites W2081855659 @default.
• W1882922602 cites W2084023405 @default.
• W1882922602 cites W2085248746 @default.
• W1882922602 cites W2086402698 @default.
• W1882922602 cites W2092985132 @default.
• W1882922602 cites W2094012882 @default.
• W1882922602 cites W2095213694 @default.
• W1882922602 cites W2108049244 @default.
• W1882922602 cites W2115847888 @default.
• W1882922602 cites W2117193299 @default.
• W1882922602 cites W2117837558 @default.
• W1882922602 cites W2124305007 @default.
• W1882922602 cites W2130488847 @default.
• W1882922602 cites W2135121318 @default.
• W1882922602 cites W2144139718 @default.
• W1882922602 cites W2151590678 @default.
• W1882922602 cites W2155509911 @default.
• W1882922602 cites W2166061461 @default.
• W1882922602 cites W2167311858 @default.
• W1882922602 cites W2314331148 @default.
• W1882922602 cites W365061267 @default.
• W1882922602 cites W4232033682 @default.
• W1882922602 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06122.x" @default.
• W1882922602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413734" @default.
• W1882922602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8223447" @default.
• W1882922602 hasPublicationYear "1993" @default.
• W1882922602 type Work @default.
• W1882922602 sameAs 1882922602 @default.
• W1882922602 citedByCount "26" @default.
• W1882922602 countsByYear W18829226022021 @default.

• next