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- W1882983235 abstract "Stable intronic sequence RNAs (sisRNAs) have been found in Xenopus tropicalis, human cell lines, and Epstein-Barr virus; however, the biological significance of sisRNAs remains poorly understood. We identify sisRNAs in Drosophila melanogaster by deep sequencing, reverse transcription polymerase chain reaction, and Northern blotting. We characterize a sisRNA (sisR-1) from the regena (rga) locus and show that it can be processed from the precursor messenger RNA (pre-mRNA). We also document a cis-natural antisense transcript (ASTR) from the rga locus, which is highly expressed in early embryos. During embryogenesis, ASTR promotes robust rga pre-mRNA expression. Interestingly, sisR-1 represses ASTR, with consequential effects on rga pre-mRNA expression. Our results suggest a model in which sisR-1 modulates its host gene expression by repressing ASTR during embryogenesis. We propose that sisR-1 belongs to a class of sisRNAs with probable regulatory activities in Drosophila." @default.
- W1882983235 created "2016-06-24" @default.
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- W1882983235 date "2015-10-26" @default.
- W1882983235 modified "2023-10-12" @default.
- W1882983235 title "Stable intronic sequence RNAs have possible regulatory roles in Drosophila melanogaster" @default.
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- W1882983235 doi "https://doi.org/10.1083/jcb.201507065" @default.
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