FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1882983705> ?p ?o ?g. }

• W1882983705 endingPage "51" @default.
• W1882983705 startingPage "37" @default.
• W1882983705 abstract "Transforming growth factor beta 1 (TGF-beta 1) and beta 2 (TGF-beta 2) are equipotent in many cell systems studies thus far. Recent data, however, show different effects elicited by these two growth factors in specific biologic systems. This investigation compares the effects of TGF-beta 1 and TGF-beta 2 bovine aortic endothelial cells (BAECs), rat epididymal fat pad microvascular endothelium (RFCs), and bovine aortic smooth muscle cells (BASCs). In two-dimensional cultures, proliferation of BAECs, BASMCs, and RFCs were all inhibited by TGF-beta 1, while in response to TGF-beta 2, BASMCs were fully inhibited, RFCs were modestly inhibited, and BAECs were unaffected. Bovine aortic endothelial cell migration was significantly inhibited by TGF-beta 1, but only slightly inhibited by TGF-beta 2. In contrast, BASMC migration was enhanced by TGF-beta 1 and was not affected by TGF-beta 2. In three-dimensional cultures, RFCs were stimulated to undergo in vitro angiogenesis in response to TGF-beta 1 and TGF-beta 2 at 10-fold higher concentrations. Three distinct receptor assays demonstrated the presence of type I and type II TGF-beta 1 cell-surface-binding proteins on BAECs, BASMCs, and RFCs. Labeled TGF-beta 1 was competed off completely with 100-fold molar excess unlabeled TGF-beta 1, but only partially with equivalent excess unlabeled TGF-beta 2. Furthermore the ratios of type I to type II TGF-beta receptors in these three vascular cell types vary from 1:1 in BAECs to 1.5:1 in RFCs to 3:1 in BASMCs and can be correlated with the differences noted in cellular responses to TGF-beta 1 and TGF-beta 2 in proliferation, migration, and in vitro angiogenic assays. These findings support the hypothesis that there are different responses to the TGF-beta s, depending on the cell type and experimental conditions as well as the TGF-beta concentration and isoform used." @default.
• W1882983705 created "2016-06-24" @default.
• W1882983705 creator A5016134289 @default.
• W1882983705 creator A5052853836 @default.
• W1882983705 creator A5082224657 @default.
• W1882983705 creator A5085800754 @default.
• W1882983705 creator A5086600579 @default.
• W1882983705 date "1991-01-01" @default.
• W1882983705 modified "2023-09-23" @default.
• W1882983705 title "Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro." @default.
• W1882983705 cites W13055029 @default.
• W1882983705 cites W1495519011 @default.
• W1882983705 cites W1499913514 @default.
• W1882983705 cites W1500595986 @default.
• W1882983705 cites W1506960040 @default.
• W1882983705 cites W1512861794 @default.
• W1882983705 cites W1524114372 @default.
• W1882983705 cites W1568292811 @default.
• W1882983705 cites W1581525584 @default.
• W1882983705 cites W1595226323 @default.
• W1882983705 cites W169622606 @default.
• W1882983705 cites W1966507279 @default.
• W1882983705 cites W1967780336 @default.
• W1882983705 cites W1973644988 @default.
• W1882983705 cites W1975776250 @default.
• W1882983705 cites W1977779461 @default.
• W1882983705 cites W1984172347 @default.
• W1882983705 cites W1986076197 @default.
• W1882983705 cites W1987408592 @default.
• W1882983705 cites W1989342170 @default.
• W1882983705 cites W1996719298 @default.
• W1882983705 cites W1997596930 @default.
• W1882983705 cites W2002513158 @default.
• W1882983705 cites W2002621910 @default.
• W1882983705 cites W2018289835 @default.
• W1882983705 cites W2021410150 @default.
• W1882983705 cites W2035819392 @default.
• W1882983705 cites W2040583312 @default.
• W1882983705 cites W2045739346 @default.
• W1882983705 cites W2046386827 @default.
• W1882983705 cites W2052589062 @default.
• W1882983705 cites W2053352199 @default.
• W1882983705 cites W2061079860 @default.
• W1882983705 cites W2064185923 @default.
• W1882983705 cites W2064566876 @default.
• W1882983705 cites W2079379519 @default.
• W1882983705 cites W2085216816 @default.
• W1882983705 cites W2087863947 @default.
• W1882983705 cites W2092671785 @default.
• W1882983705 cites W2100837269 @default.
• W1882983705 cites W2101108802 @default.
• W1882983705 cites W2104069909 @default.
• W1882983705 cites W2108104357 @default.
• W1882983705 cites W2126086593 @default.
• W1882983705 cites W2138229905 @default.
• W1882983705 cites W2144464927 @default.
• W1882983705 cites W2164279207 @default.
• W1882983705 cites W2164620775 @default.
• W1882983705 cites W2167578487 @default.
• W1882983705 cites W2291020849 @default.
• W1882983705 cites W2398996121 @default.
• W1882983705 cites W2411661304 @default.
• W1882983705 cites W2412891350 @default.
• W1882983705 cites W2895451238 @default.
• W1882983705 cites W69784355 @default.
• W1882983705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1886039" @default.
• W1882983705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1846264" @default.
• W1882983705 hasPublicationYear "1991" @default.
• W1882983705 type Work @default.
• W1882983705 sameAs 1882983705 @default.
• W1882983705 citedByCount "38" @default.
• W1882983705 countsByYear W18829837052012 @default.
• W1882983705 countsByYear W18829837052013 @default.
• W1882983705 countsByYear W18829837052014 @default.
• W1882983705 countsByYear W18829837052015 @default.
• W1882983705 crossrefType "journal-article" @default.
• W1882983705 hasAuthorship W1882983705A5016134289 @default.
• W1882983705 hasAuthorship W1882983705A5052853836 @default.
• W1882983705 hasAuthorship W1882983705A5082224657 @default.
• W1882983705 hasAuthorship W1882983705A5085800754 @default.
• W1882983705 hasAuthorship W1882983705A5086600579 @default.
• W1882983705 hasConcept C10205521 @default.
• W1882983705 hasConcept C111001777 @default.
• W1882983705 hasConcept C118131993 @default.
• W1882983705 hasConcept C126322002 @default.
• W1882983705 hasConcept C134018914 @default.
• W1882983705 hasConcept C1491633281 @default.
• W1882983705 hasConcept C170493617 @default.
• W1882983705 hasConcept C199360897 @default.
• W1882983705 hasConcept C202751555 @default.
• W1882983705 hasConcept C2776174256 @default.
• W1882983705 hasConcept C2776992346 @default.
• W1882983705 hasConcept C2778229498 @default.
• W1882983705 hasConcept C2781381406 @default.
• W1882983705 hasConcept C28328180 @default.
• W1882983705 hasConcept C41008148 @default.
• W1882983705 hasConcept C55493867 @default.
• W1882983705 hasConcept C6061869 @default.

• next