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• W1883557202 abstract "The timing of action potentials is an important determinant of information coding in the brain. The shape of the EPSP has a key influence on the temporal precision of spike generation. Here we use dynamic clamp recording and passive neuronal models to study how developmental changes in synaptic conductance waveform and intrinsic membrane properties combine to affect the EPSP and action potential generation in cerebellar granule cells. We recorded EPSCs at newly formed and mature mossy fiber-granule cell synapses. Both quantal and evoked currents showed a marked speeding of the AMPA receptor-mediated component. We also found evidence for age- and activity-dependent changes in the involvement of NMDA receptors. Although AMPA and NMDA receptors contributed to quantal EPSCs at immature synapses, multiquantal release was required to activate NMDA receptors at mature synapses, suggesting a developmental redistribution of NMDA receptors. These changes in the synaptic conductance waveform result in a faster rising EPSP and reduced spike latency in mature granule cells. Mature granule cells also have a significantly decreased input resistance, contributing to a faster decaying EPSP and a reduced spike jitter. We suggest that these concurrent developmental changes, which increase the temporal precision of EPSP-spike coupling, will increase the fidelity with which sensory information is processed within the input layer of the cerebellar cortex." @default.
• W1883557202 created "2016-06-24" @default.
• W1883557202 creator A5005623356 @default.
• W1883557202 creator A5069305015 @default.
• W1883557202 creator A5075321703 @default.
• W1883557202 creator A5076267142 @default.
• W1883557202 date "2003-07-09" @default.
• W1883557202 modified "2023-10-12" @default.
• W1883557202 title "Maturation of EPSCs and Intrinsic Membrane Properties Enhances Precision at a Cerebellar Synapse" @default.
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• W1883557202 doi "https://doi.org/10.1523/jneurosci.23-14-06074.2003" @default.
• W1883557202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740347" @default.
• W1883557202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12853426" @default.
• W1883557202 hasPublicationYear "2003" @default.
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