Matches in SemOpenAlex for { <https://semopenalex.org/work/W1883582022> ?p ?o ?g. }
- W1883582022 endingPage "745" @default.
- W1883582022 startingPage "741" @default.
- W1883582022 abstract "Abstract Ikaros, a hematopoietic transcription factor, has well defined effects on early lymphocyte development in the bone marrow and thymus. In this study we demonstrate that Ikaros is a positive regulator of Th2 cytokine gene expression in peripheral T cells. CD4+ T cells from naive Ikarosnull mice cultured under Th2-skewing conditions express the Th1 cytokine IFN-γ and have reduced IL-4, IL-5, and IL-13 expression. Ikaros directly associates with several Th2 locus regulatory regions in naive CD4+ T cells. The decreased ability to express Th2 cytokines in Ikarosnull T cells corresponds with histone 3 hypoacetylation across the Th2 cytokine locus as well as decreased GATA3 and cMaf and increased T-bet and STAT1 expression. These data support a model whereby Ikaros directly activates Th2 gene expression by promoting local chromatin accessibility during CD4+ T cell differentiation and also acts indirectly to regulate expression of Th2- and Th1-specific transcription factors." @default.
- W1883582022 created "2016-06-24" @default.
- W1883582022 creator A5027668360 @default.
- W1883582022 creator A5044314885 @default.
- W1883582022 creator A5045360268 @default.
- W1883582022 creator A5062643645 @default.
- W1883582022 creator A5071808172 @default.
- W1883582022 date "2009-01-15" @default.
- W1883582022 modified "2023-10-14" @default.
- W1883582022 title "Cutting Edge: Ikaros Is a Regulator of Th2 Cell Differentiation" @default.
- W1883582022 cites W1543604048 @default.
- W1883582022 cites W1602470456 @default.
- W1883582022 cites W1964329283 @default.
- W1883582022 cites W1971290231 @default.
- W1883582022 cites W1985187876 @default.
- W1883582022 cites W1985364817 @default.
- W1883582022 cites W1988369300 @default.
- W1883582022 cites W2020096790 @default.
- W1883582022 cites W2022618390 @default.
- W1883582022 cites W2026082697 @default.
- W1883582022 cites W2029531273 @default.
- W1883582022 cites W2031593086 @default.
- W1883582022 cites W2040544622 @default.
- W1883582022 cites W2058430303 @default.
- W1883582022 cites W2074717331 @default.
- W1883582022 cites W2086780553 @default.
- W1883582022 cites W2092263607 @default.
- W1883582022 cites W2107653794 @default.
- W1883582022 cites W2115785513 @default.
- W1883582022 cites W2119767265 @default.
- W1883582022 cites W2136278733 @default.
- W1883582022 cites W2145201730 @default.
- W1883582022 cites W2155300730 @default.
- W1883582022 cites W2168476212 @default.
- W1883582022 cites W2170927603 @default.
- W1883582022 doi "https://doi.org/10.4049/jimmunol.182.2.741" @default.
- W1883582022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2718557" @default.
- W1883582022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19124715" @default.
- W1883582022 hasPublicationYear "2009" @default.
- W1883582022 type Work @default.
- W1883582022 sameAs 1883582022 @default.
- W1883582022 citedByCount "67" @default.
- W1883582022 countsByYear W18835820222012 @default.
- W1883582022 countsByYear W18835820222013 @default.
- W1883582022 countsByYear W18835820222014 @default.
- W1883582022 countsByYear W18835820222015 @default.
- W1883582022 countsByYear W18835820222016 @default.
- W1883582022 countsByYear W18835820222017 @default.
- W1883582022 countsByYear W18835820222018 @default.
- W1883582022 countsByYear W18835820222019 @default.
- W1883582022 countsByYear W18835820222020 @default.
- W1883582022 countsByYear W18835820222021 @default.
- W1883582022 countsByYear W18835820222022 @default.
- W1883582022 countsByYear W18835820222023 @default.
- W1883582022 crossrefType "journal-article" @default.
- W1883582022 hasAuthorship W1883582022A5027668360 @default.
- W1883582022 hasAuthorship W1883582022A5044314885 @default.
- W1883582022 hasAuthorship W1883582022A5045360268 @default.
- W1883582022 hasAuthorship W1883582022A5062643645 @default.
- W1883582022 hasAuthorship W1883582022A5071808172 @default.
- W1883582022 hasBestOaLocation W18835820221 @default.
- W1883582022 hasConcept C102037460 @default.
- W1883582022 hasConcept C104317684 @default.
- W1883582022 hasConcept C109159458 @default.
- W1883582022 hasConcept C148738053 @default.
- W1883582022 hasConcept C191732599 @default.
- W1883582022 hasConcept C203014093 @default.
- W1883582022 hasConcept C2776090121 @default.
- W1883582022 hasConcept C2778070265 @default.
- W1883582022 hasConcept C2778690821 @default.
- W1883582022 hasConcept C28328180 @default.
- W1883582022 hasConcept C54355233 @default.
- W1883582022 hasConcept C64927066 @default.
- W1883582022 hasConcept C6929976 @default.
- W1883582022 hasConcept C83640560 @default.
- W1883582022 hasConcept C86339819 @default.
- W1883582022 hasConcept C86803240 @default.
- W1883582022 hasConcept C8891405 @default.
- W1883582022 hasConcept C95444343 @default.
- W1883582022 hasConceptScore W1883582022C102037460 @default.
- W1883582022 hasConceptScore W1883582022C104317684 @default.
- W1883582022 hasConceptScore W1883582022C109159458 @default.
- W1883582022 hasConceptScore W1883582022C148738053 @default.
- W1883582022 hasConceptScore W1883582022C191732599 @default.
- W1883582022 hasConceptScore W1883582022C203014093 @default.
- W1883582022 hasConceptScore W1883582022C2776090121 @default.
- W1883582022 hasConceptScore W1883582022C2778070265 @default.
- W1883582022 hasConceptScore W1883582022C2778690821 @default.
- W1883582022 hasConceptScore W1883582022C28328180 @default.
- W1883582022 hasConceptScore W1883582022C54355233 @default.
- W1883582022 hasConceptScore W1883582022C64927066 @default.
- W1883582022 hasConceptScore W1883582022C6929976 @default.
- W1883582022 hasConceptScore W1883582022C83640560 @default.
- W1883582022 hasConceptScore W1883582022C86339819 @default.
- W1883582022 hasConceptScore W1883582022C86803240 @default.
- W1883582022 hasConceptScore W1883582022C8891405 @default.
- W1883582022 hasConceptScore W1883582022C95444343 @default.
- W1883582022 hasIssue "2" @default.