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- W1883773314 abstract "Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; however, the dysregulated splicing patterns found on a genome-wide scale have until recently been less well-studied. In this review, we provide an overview of aberrant RNA splicing and its regulation in cancer. We then focus on the executors of the splicing process. Based on a comprehensive catalog of splicing factor encoding genes and analyses of available gene expression and somatic mutation data, we identify cancer-associated patterns of dysregulation. Splicing factor genes are shown to be significantly differentially expressed between cancer and corresponding normal samples, and to have reduced inter-individual expression variation in cancer. Furthermore, we identify enrichment of predicted cancer-critical genes among the splicing factors. In addition to previously described oncogenic splicing factor genes, we propose 24 novel cancer-critical splicing factors predicted from somatic mutations." @default.
- W1883773314 created "2016-06-24" @default.
- W1883773314 creator A5001644376 @default.
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- W1883773314 creator A5003756066 @default.
- W1883773314 creator A5038313341 @default.
- W1883773314 creator A5089685702 @default.
- W1883773314 date "2015-08-24" @default.
- W1883773314 modified "2023-10-14" @default.
- W1883773314 title "Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes" @default.
- W1883773314 cites W1506013368 @default.
- W1883773314 cites W1536775300 @default.
- W1883773314 cites W1551073541 @default.
- W1883773314 cites W1553241884 @default.
- W1883773314 cites W1553855319 @default.
- W1883773314 cites W1576936445 @default.
- W1883773314 cites W1588212060 @default.
- W1883773314 cites W1590070625 @default.
- W1883773314 cites W1794473041 @default.
- W1883773314 cites W1800793451 @default.
- W1883773314 cites W1816176398 @default.
- W1883773314 cites W1844925317 @default.
- W1883773314 cites W187328735 @default.
- W1883773314 cites W1907787906 @default.
- W1883773314 cites W1920712310 @default.
- W1883773314 cites W1938491657 @default.
- W1883773314 cites W1952715049 @default.
- W1883773314 cites W1964089296 @default.
- W1883773314 cites W1964847767 @default.
- W1883773314 cites W1965582460 @default.
- W1883773314 cites W1966248317 @default.
- W1883773314 cites W1966901253 @default.
- W1883773314 cites W1968044382 @default.
- W1883773314 cites W1968239355 @default.
- W1883773314 cites W1968569455 @default.
- W1883773314 cites W1970108031 @default.
- W1883773314 cites W1970455281 @default.
- W1883773314 cites W1970555584 @default.
- W1883773314 cites W1973304708 @default.
- W1883773314 cites W1975609403 @default.
- W1883773314 cites W1976689131 @default.
- W1883773314 cites W1979233636 @default.
- W1883773314 cites W1979718394 @default.
- W1883773314 cites W1981218311 @default.
- W1883773314 cites W1981506194 @default.
- W1883773314 cites W1983409515 @default.
- W1883773314 cites W1983567075 @default.
- W1883773314 cites W1984675437 @default.
- W1883773314 cites W1985585224 @default.
- W1883773314 cites W1986077139 @default.
- W1883773314 cites W1986113553 @default.
- W1883773314 cites W1986639906 @default.
- W1883773314 cites W1987374058 @default.
- W1883773314 cites W1987583118 @default.
- W1883773314 cites W1988373809 @default.
- W1883773314 cites W1989147967 @default.
- W1883773314 cites W1989174554 @default.
- W1883773314 cites W1989510858 @default.
- W1883773314 cites W1989773675 @default.
- W1883773314 cites W1990097247 @default.
- W1883773314 cites W1992137373 @default.
- W1883773314 cites W1993374643 @default.
- W1883773314 cites W1993616000 @default.
- W1883773314 cites W1994696519 @default.
- W1883773314 cites W1996361222 @default.
- W1883773314 cites W1997939700 @default.
- W1883773314 cites W1998786976 @default.
- W1883773314 cites W1998997956 @default.
- W1883773314 cites W1999609473 @default.
- W1883773314 cites W1999980789 @default.
- W1883773314 cites W2001108463 @default.
- W1883773314 cites W2001952613 @default.
- W1883773314 cites W2002879956 @default.
- W1883773314 cites W2005895083 @default.
- W1883773314 cites W2008529876 @default.
- W1883773314 cites W2009221497 @default.
- W1883773314 cites W2009258895 @default.
- W1883773314 cites W2009720434 @default.
- W1883773314 cites W2009980816 @default.
- W1883773314 cites W2010779916 @default.
- W1883773314 cites W2010852376 @default.
- W1883773314 cites W2011151090 @default.
- W1883773314 cites W2011690214 @default.
- W1883773314 cites W2011920499 @default.
- W1883773314 cites W2011941471 @default.
- W1883773314 cites W2012197353 @default.
- W1883773314 cites W2013351473 @default.
- W1883773314 cites W2014012297 @default.
- W1883773314 cites W2015207840 @default.
- W1883773314 cites W2015661539 @default.
- W1883773314 cites W2016242163 @default.
- W1883773314 cites W2018721001 @default.
- W1883773314 cites W2022495797 @default.
- W1883773314 cites W2023506303 @default.
- W1883773314 cites W2024468256 @default.
- W1883773314 cites W2025120360 @default.
- W1883773314 cites W2025137072 @default.
- W1883773314 cites W2025943989 @default.