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- W1883887341 endingPage "737" @default.
- W1883887341 startingPage "725" @default.
- W1883887341 abstract "Studies with heart rate variability have revealed interictal autonomic alterations in patients with epilepsy. In addition, epilepsy is frequently associated with ictal tachycardia or bradycardia, which sometimes precedes the onset of seizures. Ictal tachycardia is sometimes associated with electrocardiography (ECG) morphologic changes and ictal bradycardia often progresses to asystole. Such cardiac manifestations of seizures have been hypothesized as possible causes for sudden unexplained death in epilepsy (SUPEP). The present review relates to interictal and ictal cardiac manifestations of epilepsy with focus on heart rate, heart rate variability, and ECG changes. Aspects of the supporting mechanisms are discussed and attention is drawn to the interaction between central and peripheral effects, interictal autonomic conditions, ictal autonomic discharges, and administration of antiepileptic drugs in shaping the ictal cardiac changes. Because these interactions are complex and not totally understood, closer surveillance of patients and more experimental work is necessary to elucidate the mechanistic support of autonomic and cardiac changes in epilepsy, and to design better strategies to avoid their undesirable effects. It is also suggested that some of these changes could be used as predictors or markers for the onset of seizures." @default.
- W1883887341 created "2016-06-24" @default.
- W1883887341 creator A5044900404 @default.
- W1883887341 creator A5080976736 @default.
- W1883887341 date "2010-01-07" @default.
- W1883887341 modified "2023-10-01" @default.
- W1883887341 title "Autonomic alterations and cardiac changes in epilepsy" @default.
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- W1883887341 doi "https://doi.org/10.1111/j.1528-1167.2009.02479.x" @default.
- W1883887341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20067509" @default.
- W1883887341 hasPublicationYear "2010" @default.