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- W1884302798 abstract "The kidneys play a role in the synthesis and interorgan exchange of several amino acids. The quantitative importance of renal amino acid metabolism in the body is not, however, clear. We review here the role of the kidney in the interorgan exchange of amino acids, with emphasis on quantitative aspects. We reviewed relevant literature by using a computerized literature search (PubMed) and checking relevant references from the identified articles. Our own data are discussed in the context of the literature. The kidney takes up glutamine and metabolizes it to ammonia. This process is sensitive to pH and serves to maintain acid-base homeostasis and to excrete nitrogen. In this way, the metabolism of renal glutamine and ammonia is complementary to hepatic urea synthesis. Citrulline, derived from intestinal glutamine breakdown, is converted to arginine by the kidney. Renal phenylalanine uptake is followed by stoichiometric tyrosine release, and glycine uptake is accompanied by serine release. Certain administered oligopeptides (eg, glutamine dipeptides) are converted by the kidneys to their constituent components before they can be used in metabolic processes. The kidneys play an important role in the interorgan exchange of amino acids. Quantitatively, for several important amino acids, the kidneys are as important as the gut in intermediary metabolism. The kidneys may be crucial mediators of the beneficial effects of specialized, disease-specific feeding solutions such as those enriched in glutamine dipeptides." @default.
- W1884302798 created "2016-06-24" @default.
- W1884302798 creator A5017006323 @default.
- W1884302798 creator A5019509998 @default.
- W1884302798 creator A5022058638 @default.
- W1884302798 creator A5030541212 @default.
- W1884302798 creator A5066523599 @default.
- W1884302798 date "2004-02-01" @default.
- W1884302798 modified "2023-10-11" @default.
- W1884302798 title "Renal metabolism of amino acids: its role in interorgan amino acid exchange" @default.
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