FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1884312504> ?p ?o ?g. }

• W1884312504 endingPage "306" @default.
• W1884312504 startingPage "297" @default.
• W1884312504 abstract "Abstract The β2 integrin CD11a is involved in T cell-APC interactions, but the roles of CD11b, CD11c, and CD11d in such interactions have not been examined. To evaluate the roles of each CD11/CD18 integrin in T cell-APC interactions, we tested the ability of splenocytes of CD11-knockout (KO) mice to respond to staphylococcal enterotoxins (SEs), a commonly used superantigen. The defect in T cell proliferation with SEA was more severe in splenocytes from mice deficient in CD18, CD11b, or CD11d than in CD11a-deficient splenocytes, with a normal response in CD11c-deficient splenocytes. Mixing experiments showed that the defect of both CD11b-KO and CD11d-KO splenocytes was, unexpectedly, in T cells rather than in APC. Cytometric analysis failed to detect CD11b or CD11d on resting or activated T cells or on thymocytes of wild-type adult mice, nor did Abs directed to these integrins block responses in culture, suggesting that T cells educated in CD11b-KO or CD11d-KO mice were phenotypically altered. Consistent with this hypothesis, T cells from CD11b-KO and CD11d-KO splenocytes exhibited reduced intensity of CD3 and CD28 expression and decreased ratios of CD4/CD8 cells, and CD4+ T cells were reduced among CD11b-KO and CD11d-KO thymocytes. CD11b and CD11d were coexpressed on a subset of early wild-type fetal thymocytes. We postulate that transient thymocyte expression of both CD11b and CD11d is nonredundantly required for normal thymocyte and T cell development, leading to phenotypic changes in T cells that result in the reduced response to SE stimulation." @default.
• W1884312504 created "2016-06-24" @default.
• W1884312504 creator A5038579971 @default.
• W1884312504 creator A5041958759 @default.
• W1884312504 creator A5050951026 @default.
• W1884312504 creator A5052604218 @default.
• W1884312504 creator A5054724932 @default.
• W1884312504 creator A5057213122 @default.
• W1884312504 creator A5065278392 @default.
• W1884312504 creator A5065915377 @default.
• W1884312504 creator A5069804519 @default.
• W1884312504 creator A5090582198 @default.
• W1884312504 date "2004-07-01" @default.
• W1884312504 modified "2023-09-27" @default.
• W1884312504 title "Deficiency of CD11b or CD11d Results in Reduced Staphylococcal Enterotoxin-Induced T Cell Response and T Cell Phenotypic Changes" @default.
• W1884312504 cites W1479852552 @default.
• W1884312504 cites W1531483067 @default.
• W1884312504 cites W1538531198 @default.
• W1884312504 cites W1568033538 @default.
• W1884312504 cites W1574409102 @default.
• W1884312504 cites W1645222688 @default.
• W1884312504 cites W1669231937 @default.
• W1884312504 cites W1721686426 @default.
• W1884312504 cites W1810482515 @default.
• W1884312504 cites W1846819594 @default.
• W1884312504 cites W1942731643 @default.
• W1884312504 cites W1969870278 @default.
• W1884312504 cites W1970537509 @default.
• W1884312504 cites W1972276563 @default.
• W1884312504 cites W1981571305 @default.
• W1884312504 cites W1983766338 @default.
• W1884312504 cites W1984051873 @default.
• W1884312504 cites W1989194294 @default.
• W1884312504 cites W1994103391 @default.
• W1884312504 cites W2001803423 @default.
• W1884312504 cites W2004212058 @default.
• W1884312504 cites W2007705388 @default.
• W1884312504 cites W2017376731 @default.
• W1884312504 cites W2020893836 @default.
• W1884312504 cites W2029231027 @default.
• W1884312504 cites W2042835203 @default.
• W1884312504 cites W2044031108 @default.
• W1884312504 cites W2047613146 @default.
• W1884312504 cites W2049478058 @default.
• W1884312504 cites W2056744985 @default.
• W1884312504 cites W2070327080 @default.
• W1884312504 cites W2073028945 @default.
• W1884312504 cites W2074732853 @default.
• W1884312504 cites W2086417745 @default.
• W1884312504 cites W2106007373 @default.
• W1884312504 cites W2127447114 @default.
• W1884312504 cites W2139998550 @default.
• W1884312504 cites W2142490832 @default.
• W1884312504 cites W2142980500 @default.
• W1884312504 cites W2144924707 @default.
• W1884312504 cites W2146981926 @default.
• W1884312504 cites W2148406205 @default.
• W1884312504 cites W2151403120 @default.
• W1884312504 cites W2151710495 @default.
• W1884312504 cites W2159180573 @default.
• W1884312504 cites W2170420780 @default.
• W1884312504 cites W2172561316 @default.
• W1884312504 cites W2187060917 @default.
• W1884312504 cites W4313422355 @default.
• W1884312504 cites W75858226 @default.
• W1884312504 doi "https://doi.org/10.4049/jimmunol.173.1.297" @default.
• W1884312504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15210787" @default.
• W1884312504 hasPublicationYear "2004" @default.
• W1884312504 type Work @default.
• W1884312504 sameAs 1884312504 @default.
• W1884312504 citedByCount "71" @default.
• W1884312504 countsByYear W18843125042012 @default.
• W1884312504 countsByYear W18843125042013 @default.
• W1884312504 countsByYear W18843125042014 @default.
• W1884312504 countsByYear W18843125042015 @default.
• W1884312504 countsByYear W18843125042016 @default.
• W1884312504 countsByYear W18843125042017 @default.
• W1884312504 countsByYear W18843125042018 @default.
• W1884312504 countsByYear W18843125042019 @default.
• W1884312504 countsByYear W18843125042020 @default.
• W1884312504 countsByYear W18843125042021 @default.
• W1884312504 countsByYear W18843125042022 @default.
• W1884312504 crossrefType "journal-article" @default.
• W1884312504 hasAuthorship W1884312504A5038579971 @default.
• W1884312504 hasAuthorship W1884312504A5041958759 @default.
• W1884312504 hasAuthorship W1884312504A5050951026 @default.
• W1884312504 hasAuthorship W1884312504A5052604218 @default.
• W1884312504 hasAuthorship W1884312504A5054724932 @default.
• W1884312504 hasAuthorship W1884312504A5057213122 @default.
• W1884312504 hasAuthorship W1884312504A5065278392 @default.
• W1884312504 hasAuthorship W1884312504A5065915377 @default.
• W1884312504 hasAuthorship W1884312504A5069804519 @default.
• W1884312504 hasAuthorship W1884312504A5090582198 @default.
• W1884312504 hasBestOaLocation W18843125041 @default.
• W1884312504 hasConcept C114684123 @default.
• W1884312504 hasConcept C148125776 @default.
• W1884312504 hasConcept C153911025 @default.
• W1884312504 hasConcept C167672396 @default.

• next