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- W1884454078 abstract "Oligopeptide transporters serve important functions in nutrition and pharmacology. In particular, these transporters help maintain the homeostasis of peptides. The peptide-transporter PEPT2 is a high-affinity and low-capacity type oligopeptide transporter from the proton-coupled oligopeptide transporter family. PEPT2 has recently received attention because of its potential application in targeted drug delivery. PEPT2 is widely distributed in kidney, central nervous system, and lung of organisms. In general, all dipeptides, tripeptides, and peptide-like drugs such as β-lactam antibiotics and angiotensin-converting enzyme inhibitors could be mediated and transported as a substrate of PEPT2. The design of many extant drugs and prodrugs is based on the substrate structure of PEPT2 to accelerate absorption via peptide transporters. Thus, this paper summarizes the substrate features of PEPT2 to promote the rational design of drugs and prodrugs that target peptide transporters." @default.
- W1884454078 created "2016-06-24" @default.
- W1884454078 creator A5053665396 @default.
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- W1884454078 date "2015-01-01" @default.
- W1884454078 modified "2023-09-27" @default.
- W1884454078 title "Substrates of the human oligopeptide transporter hPEPT2" @default.
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- W1884454078 doi "https://doi.org/10.5582/bst.2015.01078" @default.
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