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- W1884583294 abstract "Abstract Retrorectal cyst hamartoma (RCH) is a rare benign cystic lesion located in the retrorectal space. Malignancy arising in such lesions is very uncommon. In this study, 2 cases of mucinous adenocarcinoma arising in RCH are presented. In one case, dysplastic epithelium lined the cyst wall, surrounding the area of carcinoma and suggesting a dysplasia-carcinoma progression in RCH. Adenocarcinoma and the dysplastic epithelium were strongly positive for p53 and Ki-67 and showed negative staining for p21 by immunohistochemistry. These findings are suggestive of a mutation in the p53 gene in the adenocarcinoma and in dysplastic epithelium lining the cysts, similar to the dysplasia-carcinoma sequence described for the development of colonic adenocarcinoma." @default.
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- W1884583294 date "2001-10-01" @default.
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- W1884583294 title "<i>p53</i> Mutation in Adenocarcinoma Arising in Retrorectal Cyst Hamartoma (Tailgut Cyst)" @default.
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- W1884583294 doi "https://doi.org/10.5858/2001-125-1361-pmiaai" @default.
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