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• W188465600 abstract "Significant advances have been made during the last 20 yr in understanding the mechanisms of adenosine receptor-mediated signal transduction at the level of the plasma membrane. The pioneering studies in the early 1970s by Rall, Daly, Schwabe, and Fain clearly established that adenosine and its analogs could modulate both cyclic AMP levels in intact cells and adenylate cyclase activity in broken cell preparations. Systematic studies by Londos and Wolff (1977) estab­lished that the effects of adenosine on the intact cell could be separated into those that could be considered to be receptor-mediated (by the so-called “R-site”), and thus, amenable to the conceptual and method­ological strategies available for the study of such processes, and those that could be viewed as being mediated by the so-called “P-sites,” which displayed few of the regulatory features exhibited by previ­ously characterized extracellular receptors. Achieving this discrimi­nation set the stage for the subsequent separation of the conventional (“R-site”) receptor into two subtypes termed Ri and Ra *, which inhibited and stimulated, with differing pharmacological profiles, respec­tively, adenylate cyclase activity in plasma membranes isolated from a wide variety of cells (Londos et al., 1980). At nearly the same time, Van Calker et al. (1979) proposed the same subclassification of the “R-site” based on studies of cyclic AMP production in response to a range of adenosine analogs in two cultured cell lines." @default.
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• W188465600 date "1990-01-01" @default.
• W188465600 modified "2023-09-25" @default.
• W188465600 title "Signal Transduction Mechanisms for Adenosine" @default.
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• W188465600 doi "https://doi.org/10.1007/978-1-4612-4504-9_4" @default.
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