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- W188473334 abstract "To explore the levels of adiponectin (APN), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in first episode drug naїve schizophrenics and further examine the role of adipocytokines in schizophrenia.Ninety-six normal weight schizophrenics and 22 overweight/obese ones from First Affiliated Hospital, Zhengzhou University and 60 healthy controls were enrolled. Serum levels of IL-1β, IL-6, TNF-α and APN were measured with enzyme linked immunosorbent assay (ELISA).Serum levels of IL-1β, IL-6 and TNF-α in normal weight schizophrenics (54 ± 13, 34 ± 12, 48 ± 18) pg/ml and overweight/obese schizophrenics (71 ± 21, 40 ± 12, 53 ± 18) pg/ml were significantly higher than those in the controls (23 ± 16, 16 ± 7, 32 ± 15) pg/ml (P < 0.05). Serum levels of IL-1β and IL-6 in overweight/obese schizophrenics were significantly higher than those in normal weight schizophrenics (P < 0.05). Serum level of adiponectin in normal weight schizophrenics was significantly higher than that in control group [(12 ± 4) vs (9 ± 4) pg/ml, P < 0.05].The serum levels of APN, IL-1β, IL-6 and TNF-α increase in first episode drug naїve schizophrenics. It suggests that an inflammatory response mediated by adipocytokines. APN may play a pro-inflammatory role in schizophrenia." @default.
- W188473334 created "2016-06-24" @default.
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- W188473334 date "2013-11-05" @default.
- W188473334 modified "2023-10-11" @default.
- W188473334 title "[Study of adiponectin, IL-1β, IL-6 and TNF-α in first episode drug naїve schizophrenia]." @default.
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