FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1884746789> ?p ?o ?g. }

• W1884746789 endingPage "271" @default.
• W1884746789 startingPage "263" @default.
• W1884746789 abstract "Summary Caspase‐like proteases are key initiators and executioners of programmed cell death ( PCD ), which is initiated by environmental stimuli and manifests in organisms ranging from unicellular microbes to higher eukaryotes. A rchaea had been absent from the caspase inheritance discussion due to a lack of gene homologues. We recently demonstrated extremely high, basal caspase‐like catalytic activity in the model haloarcheon, H aloferax volcanii , which was linked to the cellular stress response and was widespread among diverse A rchaea . Here, we rigorously tested the catalytic specificity of the observed archaeal caspase‐like activities using hydrolytic assays with a diverse suite of protease substrates and inhibitors compared with known model serine and cysteine proteases (trypsin, cathepsin, papain, and human caspase‐8). Our experiments demonstrate that exponentially growing H . volcanii possesses a highly specific caspase‐like activity that most closely resembles caspase‐4, is preferentially inhibited by the pan‐caspase inhibitor, zVAD ‐ FMK , and has no cross‐reactivity with other known protease families. Our findings firmly root the extremely high levels of caspase‐like activity as the dominant proteolytic activity in this extreme haloarcheaon, thereby providing further support for housekeeping functions in H aloarchaea . Given the deep archaeal roots of eukaryotes, we suggest that this activity served as a foundation for stress pathways in higher organisms." @default.
• W1884746789 created "2016-06-24" @default.
• W1884746789 creator A5004663618 @default.
• W1884746789 creator A5026906359 @default.
• W1884746789 creator A5059955159 @default.
• W1884746789 date "2012-11-30" @default.
• W1884746789 modified "2023-10-17" @default.
• W1884746789 title "Specificity of archaeal caspase activity in the extreme halophile <i> <scp>H</scp> aloferax volcanii </i>" @default.
• W1884746789 cites W1942214720 @default.
• W1884746789 cites W1969221769 @default.
• W1884746789 cites W1974843169 @default.
• W1884746789 cites W1996877429 @default.
• W1884746789 cites W2000383699 @default.
• W1884746789 cites W2005715606 @default.
• W1884746789 cites W2007703737 @default.
• W1884746789 cites W2014189709 @default.
• W1884746789 cites W2016151751 @default.
• W1884746789 cites W2018412575 @default.
• W1884746789 cites W2024105041 @default.
• W1884746789 cites W2024870937 @default.
• W1884746789 cites W2028582699 @default.
• W1884746789 cites W2036943360 @default.
• W1884746789 cites W2039058558 @default.
• W1884746789 cites W2041022386 @default.
• W1884746789 cites W2048795083 @default.
• W1884746789 cites W2053892145 @default.
• W1884746789 cites W2058788374 @default.
• W1884746789 cites W2061497413 @default.
• W1884746789 cites W2062835321 @default.
• W1884746789 cites W2064127449 @default.
• W1884746789 cites W2070152120 @default.
• W1884746789 cites W2084804915 @default.
• W1884746789 cites W2089843401 @default.
• W1884746789 cites W2089857479 @default.
• W1884746789 cites W2090951206 @default.
• W1884746789 cites W2093035634 @default.
• W1884746789 cites W2095768111 @default.
• W1884746789 cites W2102109561 @default.
• W1884746789 cites W2102560754 @default.
• W1884746789 cites W2106906885 @default.
• W1884746789 cites W2111261116 @default.
• W1884746789 cites W2115137627 @default.
• W1884746789 cites W2120798255 @default.
• W1884746789 cites W2122826329 @default.
• W1884746789 cites W2122976061 @default.
• W1884746789 cites W2126184219 @default.
• W1884746789 cites W2128262451 @default.
• W1884746789 cites W2131792202 @default.
• W1884746789 cites W2132899951 @default.
• W1884746789 cites W2133821029 @default.
• W1884746789 cites W2134302316 @default.
• W1884746789 cites W2134929227 @default.
• W1884746789 cites W2138640224 @default.
• W1884746789 cites W2146870223 @default.
• W1884746789 cites W2161344663 @default.
• W1884746789 cites W2169018657 @default.
• W1884746789 cites W3023731605 @default.
• W1884746789 cites W952376717 @default.
• W1884746789 doi "https://doi.org/10.1111/1758-2229.12010" @default.
• W1884746789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3615174" @default.
• W1884746789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23565123" @default.
• W1884746789 hasPublicationYear "2012" @default.
• W1884746789 type Work @default.
• W1884746789 sameAs 1884746789 @default.
• W1884746789 citedByCount "8" @default.
• W1884746789 countsByYear W18847467892015 @default.
• W1884746789 countsByYear W18847467892016 @default.
• W1884746789 countsByYear W18847467892017 @default.
• W1884746789 countsByYear W18847467892019 @default.
• W1884746789 countsByYear W18847467892022 @default.
• W1884746789 crossrefType "journal-article" @default.
• W1884746789 hasAuthorship W1884746789A5004663618 @default.
• W1884746789 hasAuthorship W1884746789A5026906359 @default.
• W1884746789 hasAuthorship W1884746789A5059955159 @default.
• W1884746789 hasBestOaLocation W18847467892 @default.
• W1884746789 hasConcept C104317684 @default.
• W1884746789 hasConcept C145770059 @default.
• W1884746789 hasConcept C155863897 @default.
• W1884746789 hasConcept C181199279 @default.
• W1884746789 hasConcept C182220744 @default.
• W1884746789 hasConcept C190283241 @default.
• W1884746789 hasConcept C2776179084 @default.
• W1884746789 hasConcept C2776414213 @default.
• W1884746789 hasConcept C2776714187 @default.
• W1884746789 hasConcept C2777283782 @default.
• W1884746789 hasConcept C2779926853 @default.
• W1884746789 hasConcept C31573885 @default.
• W1884746789 hasConcept C550995028 @default.
• W1884746789 hasConcept C55493867 @default.
• W1884746789 hasConcept C86803240 @default.
• W1884746789 hasConcept C95444343 @default.
• W1884746789 hasConcept C98424977 @default.
• W1884746789 hasConceptScore W1884746789C104317684 @default.
• W1884746789 hasConceptScore W1884746789C145770059 @default.
• W1884746789 hasConceptScore W1884746789C155863897 @default.
• W1884746789 hasConceptScore W1884746789C181199279 @default.
• W1884746789 hasConceptScore W1884746789C182220744 @default.
• W1884746789 hasConceptScore W1884746789C190283241 @default.

• next