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- W1884773148 abstract "Abstract The STAT6 transcription factor is essential for the development of protective immunity; however, the consequences of its activity can also contribute to the pathogenesis of autoimmune disease. Tyrosine phosphorylation is known to activate STAT6 in response to cytokine stimulation, but there is a gap in our understanding of the mechanisms by which it enters the nucleus. In this study, live cell imaging was used in conjunction with photobleaching techniques to demonstrate the continual nuclear import of STAT6, independent of tyrosine phosphorylation. The protein domain required for nuclear entry includes the coiled coil region of STAT6 and functions similarly before or after cytokine stimulation. The dynamic nuclear shuttling of STAT6 seems to be mediated by the classical importin-α–importin-β1 system. Although STAT6 is imported to the nucleus continually, it accumulates in the nucleus following tyrosine phosphorylation as a result of its ability to bind DNA. These findings will impact diagnostic approaches and strategies to block the deleterious effects of STAT6 in autoimmunity." @default.
- W1884773148 created "2016-06-24" @default.
- W1884773148 creator A5008365101 @default.
- W1884773148 creator A5033107572 @default.
- W1884773148 date "2010-07-01" @default.
- W1884773148 modified "2023-10-13" @default.
- W1884773148 title "Live Cell Imaging Reveals Continuous STAT6 Nuclear Trafficking" @default.
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- W1884773148 doi "https://doi.org/10.4049/jimmunol.0903323" @default.
- W1884773148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2891132" @default.
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