Matches in SemOpenAlex for { <https://semopenalex.org/work/W1884991565> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1884991565 endingPage "2287" @default.
- W1884991565 startingPage "2284" @default.
- W1884991565 abstract "The rate of progression from islet autoimmunity to clinical type 1 diabetes depends on the rate of beta cell destruction. The HLA-A*24 gene is associated with early diabetes onset, but previous studies have shown attenuated humoral responses to islet antigens in individuals with both recent and long-standing type 1 diabetes carrying HLA-A*24. We aimed to establish whether HLA-A*24 is also associated with attenuated humoral responses in individuals at high risk of type 1 diabetes.We established HLA-A*24, DQ and rs9258750 (an HLA-A*24 tagged single-nucleotide polymorphism) genotype, as well as GAD, zinc transporter 8 (ZnT8), insulin, islet antigen-2 (IA-2), and IA-2β autoantibody status in 373 islet cell antibody-positive first-degree relatives participating in the European Nicotinamide Diabetes Intervention Trial.Univariate regression analyses showed that humoral responses to GAD, ZnT8 and insulin were less common in relatives carrying HLA-A*24. The prevalence of GAD and ZnT8 autoantibodies remained negatively associated with HLA-A*24 and rs9258750 after adjusting for age, sex, proband relationship and HLA class II genotype.HLA-A*24 is associated with attenuated humoral responses in individuals at high risk of type 1 diabetes, and this may reflect a distinct phenotype of rapid beta cell loss." @default.
- W1884991565 created "2016-06-24" @default.
- W1884991565 creator A5018581197 @default.
- W1884991565 creator A5025489705 @default.
- W1884991565 creator A5059522259 @default.
- W1884991565 creator A5073601688 @default.
- W1884991565 creator A5077088028 @default.
- W1884991565 creator A5090416004 @default.
- W1884991565 creator A5091334433 @default.
- W1884991565 date "2015-07-30" @default.
- W1884991565 modified "2023-10-14" @default.
- W1884991565 title "Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes" @default.
- W1884991565 cites W2028009297 @default.
- W1884991565 cites W2055612236 @default.
- W1884991565 cites W2061283329 @default.
- W1884991565 cites W2089319494 @default.
- W1884991565 cites W2095256598 @default.
- W1884991565 cites W2102586642 @default.
- W1884991565 cites W2107053825 @default.
- W1884991565 cites W2117003890 @default.
- W1884991565 cites W2145473674 @default.
- W1884991565 cites W2160123341 @default.
- W1884991565 cites W2162600022 @default.
- W1884991565 doi "https://doi.org/10.1007/s00125-015-3702-9" @default.
- W1884991565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26224099" @default.
- W1884991565 hasPublicationYear "2015" @default.
- W1884991565 type Work @default.
- W1884991565 sameAs 1884991565 @default.
- W1884991565 citedByCount "7" @default.
- W1884991565 countsByYear W18849915652016 @default.
- W1884991565 countsByYear W18849915652018 @default.
- W1884991565 countsByYear W18849915652019 @default.
- W1884991565 countsByYear W18849915652021 @default.
- W1884991565 countsByYear W18849915652022 @default.
- W1884991565 countsByYear W18849915652023 @default.
- W1884991565 crossrefType "journal-article" @default.
- W1884991565 hasAuthorship W1884991565A5018581197 @default.
- W1884991565 hasAuthorship W1884991565A5025489705 @default.
- W1884991565 hasAuthorship W1884991565A5059522259 @default.
- W1884991565 hasAuthorship W1884991565A5073601688 @default.
- W1884991565 hasAuthorship W1884991565A5077088028 @default.
- W1884991565 hasAuthorship W1884991565A5090416004 @default.
- W1884991565 hasAuthorship W1884991565A5091334433 @default.
- W1884991565 hasBestOaLocation W18849915651 @default.
- W1884991565 hasConcept C126322002 @default.
- W1884991565 hasConcept C134018914 @default.
- W1884991565 hasConcept C147483822 @default.
- W1884991565 hasConcept C159654299 @default.
- W1884991565 hasConcept C163764329 @default.
- W1884991565 hasConcept C165220095 @default.
- W1884991565 hasConcept C188280979 @default.
- W1884991565 hasConcept C203014093 @default.
- W1884991565 hasConcept C2777180221 @default.
- W1884991565 hasConcept C2780130043 @default.
- W1884991565 hasConcept C2781232474 @default.
- W1884991565 hasConcept C555293320 @default.
- W1884991565 hasConcept C71924100 @default.
- W1884991565 hasConcept C86803240 @default.
- W1884991565 hasConceptScore W1884991565C126322002 @default.
- W1884991565 hasConceptScore W1884991565C134018914 @default.
- W1884991565 hasConceptScore W1884991565C147483822 @default.
- W1884991565 hasConceptScore W1884991565C159654299 @default.
- W1884991565 hasConceptScore W1884991565C163764329 @default.
- W1884991565 hasConceptScore W1884991565C165220095 @default.
- W1884991565 hasConceptScore W1884991565C188280979 @default.
- W1884991565 hasConceptScore W1884991565C203014093 @default.
- W1884991565 hasConceptScore W1884991565C2777180221 @default.
- W1884991565 hasConceptScore W1884991565C2780130043 @default.
- W1884991565 hasConceptScore W1884991565C2781232474 @default.
- W1884991565 hasConceptScore W1884991565C555293320 @default.
- W1884991565 hasConceptScore W1884991565C71924100 @default.
- W1884991565 hasConceptScore W1884991565C86803240 @default.
- W1884991565 hasIssue "10" @default.
- W1884991565 hasLocation W18849915651 @default.
- W1884991565 hasLocation W18849915652 @default.
- W1884991565 hasOpenAccess W1884991565 @default.
- W1884991565 hasPrimaryLocation W18849915651 @default.
- W1884991565 hasRelatedWork W199962162 @default.
- W1884991565 hasRelatedWork W2035871243 @default.
- W1884991565 hasRelatedWork W2069537429 @default.
- W1884991565 hasRelatedWork W2103106596 @default.
- W1884991565 hasRelatedWork W2104934137 @default.
- W1884991565 hasRelatedWork W2117055080 @default.
- W1884991565 hasRelatedWork W2121441836 @default.
- W1884991565 hasRelatedWork W2153261516 @default.
- W1884991565 hasRelatedWork W3190719821 @default.
- W1884991565 hasRelatedWork W4300815327 @default.
- W1884991565 hasVolume "58" @default.
- W1884991565 isParatext "false" @default.
- W1884991565 isRetracted "false" @default.
- W1884991565 magId "1884991565" @default.
- W1884991565 workType "article" @default.