FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1885155229> ?p ?o ?g. }

• W1885155229 endingPage "2419" @default.
• W1885155229 startingPage "2419" @default.
• W1885155229 abstract "The reasons for the high frequency of perineural invasion and the presence of pain in pancreatic cancer are still not clear. Nerve growth factor (NGF) and its high-affinity receptor TrkA are involved in stimulating epithelial cancer cell growth and perineural invasion, as well as in pain generation in chronic benign disorders.NGF and TrkA were examined by Northern blot analysis, in situ hybridization, and immunohistochemistry in 27 normal and 37 pancreatic cancer tissue samples. The molecular findings were correlated with the degree of perineural invasion, pain, and histopathologic tumor characteristics.Northern blot analysis indicated that NGF and TrkA mRNA levels were increased 2.7-fold and 5.6-fold, respectively (P <.05 and P <.05), in pancreatic cancer tissues compared with the normal pancreas tissue. As shown by in situ hybridization and immunohistochemistry, NGF was strongly present in the cytoplasm of pancreatic cancer cells. TrkA was intensely present in the perineurium of pancreatic nerves but not in the cancer cells. There was no difference in NGF and TrkA expression between early (stages I and II) and advanced (stage III) tumor stages and between well-/moderately differentiated (grades 1 and 2) and poorly differentiated (grade 3) tumors. However, tumors with high NGF/TrkA expression levels exhibited more frequent perineural invasion (P <.01). Furthermore, increased NGF/TrkA expression levels were associated with a higher degree of pain (P <. 01).Enhanced expression of the NGF/TrkA system may influence perineural invasion and may contribute to the pain syndrome in human pancreatic cancer." @default.
• W1885155229 created "2016-06-24" @default.
• W1885155229 creator A5008215786 @default.
• W1885155229 creator A5036032282 @default.
• W1885155229 creator A5044271023 @default.
• W1885155229 creator A5052428479 @default.
• W1885155229 creator A5055361781 @default.
• W1885155229 creator A5056808839 @default.
• W1885155229 creator A5089608755 @default.
• W1885155229 date "1999-08-01" @default.
• W1885155229 modified "2023-10-14" @default.
• W1885155229 title "Nerve Growth Factor Expression Correlates With Perineural Invasion and Pain in Human Pancreatic Cancer" @default.
• W1885155229 cites W1483254497 @default.
• W1885155229 cites W1525488097 @default.
• W1885155229 cites W1566222449 @default.
• W1885155229 cites W1941609444 @default.
• W1885155229 cites W1966917600 @default.
• W1885155229 cites W1973828578 @default.
• W1885155229 cites W1977008585 @default.
• W1885155229 cites W1989231576 @default.
• W1885155229 cites W1999886002 @default.
• W1885155229 cites W2001005803 @default.
• W1885155229 cites W2011924852 @default.
• W1885155229 cites W2012496512 @default.
• W1885155229 cites W2014898471 @default.
• W1885155229 cites W2016840090 @default.
• W1885155229 cites W2037831105 @default.
• W1885155229 cites W2039812926 @default.
• W1885155229 cites W2040094076 @default.
• W1885155229 cites W2051330399 @default.
• W1885155229 cites W2059979075 @default.
• W1885155229 cites W2061438510 @default.
• W1885155229 cites W2063678044 @default.
• W1885155229 cites W2063695629 @default.
• W1885155229 cites W2066613509 @default.
• W1885155229 cites W2067313865 @default.
• W1885155229 cites W2074471004 @default.
• W1885155229 cites W2086159324 @default.
• W1885155229 cites W2091309613 @default.
• W1885155229 cites W2099173554 @default.
• W1885155229 cites W2104936243 @default.
• W1885155229 cites W2114837170 @default.
• W1885155229 cites W2126206097 @default.
• W1885155229 cites W2128077493 @default.
• W1885155229 cites W2149290144 @default.
• W1885155229 cites W2155041335 @default.
• W1885155229 cites W2168315009 @default.
• W1885155229 cites W2321664402 @default.
• W1885155229 cites W2326166713 @default.
• W1885155229 cites W335061608 @default.
• W1885155229 doi "https://doi.org/10.1200/jco.1999.17.8.2419" @default.
• W1885155229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10561305" @default.
• W1885155229 hasPublicationYear "1999" @default.
• W1885155229 type Work @default.
• W1885155229 sameAs 1885155229 @default.
• W1885155229 citedByCount "212" @default.
• W1885155229 countsByYear W18851552292012 @default.
• W1885155229 countsByYear W18851552292013 @default.
• W1885155229 countsByYear W18851552292014 @default.
• W1885155229 countsByYear W18851552292015 @default.
• W1885155229 countsByYear W18851552292016 @default.
• W1885155229 countsByYear W18851552292017 @default.
• W1885155229 countsByYear W18851552292018 @default.
• W1885155229 countsByYear W18851552292019 @default.
• W1885155229 countsByYear W18851552292020 @default.
• W1885155229 countsByYear W18851552292021 @default.
• W1885155229 countsByYear W18851552292022 @default.
• W1885155229 countsByYear W18851552292023 @default.
• W1885155229 crossrefType "journal-article" @default.
• W1885155229 hasAuthorship W1885155229A5008215786 @default.
• W1885155229 hasAuthorship W1885155229A5036032282 @default.
• W1885155229 hasAuthorship W1885155229A5044271023 @default.
• W1885155229 hasAuthorship W1885155229A5052428479 @default.
• W1885155229 hasAuthorship W1885155229A5055361781 @default.
• W1885155229 hasAuthorship W1885155229A5056808839 @default.
• W1885155229 hasAuthorship W1885155229A5089608755 @default.
• W1885155229 hasConcept C104317684 @default.
• W1885155229 hasConcept C105580179 @default.
• W1885155229 hasConcept C105702510 @default.
• W1885155229 hasConcept C121608353 @default.
• W1885155229 hasConcept C126322002 @default.
• W1885155229 hasConcept C142724271 @default.
• W1885155229 hasConcept C170493617 @default.
• W1885155229 hasConcept C171034665 @default.
• W1885155229 hasConcept C204232928 @default.
• W1885155229 hasConcept C2777154038 @default.
• W1885155229 hasConcept C2778423431 @default.
• W1885155229 hasConcept C2779366703 @default.
• W1885155229 hasConcept C2780210213 @default.
• W1885155229 hasConcept C3018498973 @default.
• W1885155229 hasConcept C502942594 @default.
• W1885155229 hasConcept C55493867 @default.
• W1885155229 hasConcept C71924100 @default.
• W1885155229 hasConcept C81439078 @default.
• W1885155229 hasConcept C86803240 @default.
• W1885155229 hasConceptScore W1885155229C104317684 @default.
• W1885155229 hasConceptScore W1885155229C105580179 @default.
• W1885155229 hasConceptScore W1885155229C105702510 @default.

• next