FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1885195743> ?p ?o ?g. }

• W1885195743 endingPage "560" @default.
• W1885195743 startingPage "539" @default.
• W1885195743 abstract "RNA interference (RNAi) is a naturally occurring mechanism for gene silencing induced by the presence of short interfering RNA (siRNA). RNAi is an endogenous catalytic pathway that is triggered by double-stranded RNA (dsRNA). The trigger can occur naturally, as in the case of a cellular infection by a dsRNA virus, or by the intentional introduction of dsRNA to induce user-directed degradation of the cognate transcript(s). RNAi is fundamentally a two-step process. The first step involves the master enzyme in the RNAi process, a type III endoribonuclease aptly named Dicer. This enzyme is involved in the ATP-dependent digestion of longer dsRNA into 21 to 23 bp siRNA molecules with characteristic 3΄ dinucleotide overhangs on both strands. In the second step, siRNA, regardless of the source, becomes part of a multicomponent RNA-induced silencing complex (RISC). The use of RNAi as a means of studying the effects of gene expression in a cell or in an organism is occasionally called reverse genetics, the goal of which is to determine the consequences for a cell when a protein is not produced. In other words, the function of a gene can often be discovered by silencing it. The overall RNAi efficiency in an experiment is also a function of the abundance and the stability of both the target mRNA and the encoded protein, and the precise region of the mRNA targeted for scission." @default.
• W1885195743 created "2016-06-24" @default.
• W1885195743 creator A5003710396 @default.
• W1885195743 date "2010-01-01" @default.
• W1885195743 modified "2023-10-14" @default.
• W1885195743 title "RNAi" @default.
• W1885195743 cites W130267474 @default.
• W1885195743 cites W1515466910 @default.
• W1885195743 cites W1517480469 @default.
• W1885195743 cites W1611419331 @default.
• W1885195743 cites W1647075334 @default.
• W1885195743 cites W1871934956 @default.
• W1885195743 cites W1916491745 @default.
• W1885195743 cites W1966543080 @default.
• W1885195743 cites W1974861468 @default.
• W1885195743 cites W1981402816 @default.
• W1885195743 cites W1988227196 @default.
• W1885195743 cites W1988967884 @default.
• W1885195743 cites W1990548509 @default.
• W1885195743 cites W2009623058 @default.
• W1885195743 cites W2025635760 @default.
• W1885195743 cites W2027235289 @default.
• W1885195743 cites W2034224544 @default.
• W1885195743 cites W2038783205 @default.
• W1885195743 cites W2045450761 @default.
• W1885195743 cites W2050717506 @default.
• W1885195743 cites W2057929910 @default.
• W1885195743 cites W2058711543 @default.
• W1885195743 cites W2062498561 @default.
• W1885195743 cites W2070792578 @default.
• W1885195743 cites W2079967105 @default.
• W1885195743 cites W2082997857 @default.
• W1885195743 cites W2089001345 @default.
• W1885195743 cites W2095461860 @default.
• W1885195743 cites W2097671956 @default.
• W1885195743 cites W2101566480 @default.
• W1885195743 cites W2105444747 @default.
• W1885195743 cites W2120778382 @default.
• W1885195743 cites W2127497651 @default.
• W1885195743 cites W2137483650 @default.
• W1885195743 cites W2138664009 @default.
• W1885195743 cites W2138845961 @default.
• W1885195743 cites W2146642335 @default.
• W1885195743 cites W2147620906 @default.
• W1885195743 cites W2148312059 @default.
• W1885195743 cites W2149871164 @default.
• W1885195743 cites W2152993806 @default.
• W1885195743 cites W2153747430 @default.
• W1885195743 cites W2166903671 @default.
• W1885195743 cites W2171790482 @default.
• W1885195743 doi "https://doi.org/10.1016/b978-0-12-374727-3.00023-1" @default.
• W1885195743 hasPublicationYear "2010" @default.
• W1885195743 type Work @default.
• W1885195743 sameAs 1885195743 @default.
• W1885195743 citedByCount "6" @default.
• W1885195743 countsByYear W18851957432020 @default.
• W1885195743 countsByYear W18851957432021 @default.
• W1885195743 countsByYear W18851957432022 @default.
• W1885195743 countsByYear W18851957432023 @default.
• W1885195743 crossrefType "book-chapter" @default.
• W1885195743 hasAuthorship W1885195743A5003710396 @default.
• W1885195743 hasConcept C104317684 @default.
• W1885195743 hasConcept C10879258 @default.
• W1885195743 hasConcept C119056186 @default.
• W1885195743 hasConcept C139278185 @default.
• W1885195743 hasConcept C153911025 @default.
• W1885195743 hasConcept C155330019 @default.
• W1885195743 hasConcept C166703698 @default.
• W1885195743 hasConcept C172827444 @default.
• W1885195743 hasConcept C201853390 @default.
• W1885195743 hasConcept C2191507 @default.
• W1885195743 hasConcept C22615655 @default.
• W1885195743 hasConcept C2779867133 @default.
• W1885195743 hasConcept C2780102198 @default.
• W1885195743 hasConcept C54355233 @default.
• W1885195743 hasConcept C60723119 @default.
• W1885195743 hasConcept C67705224 @default.
• W1885195743 hasConcept C86803240 @default.
• W1885195743 hasConcept C95444343 @default.
• W1885195743 hasConceptScore W1885195743C104317684 @default.
• W1885195743 hasConceptScore W1885195743C10879258 @default.
• W1885195743 hasConceptScore W1885195743C119056186 @default.
• W1885195743 hasConceptScore W1885195743C139278185 @default.
• W1885195743 hasConceptScore W1885195743C153911025 @default.
• W1885195743 hasConceptScore W1885195743C155330019 @default.
• W1885195743 hasConceptScore W1885195743C166703698 @default.
• W1885195743 hasConceptScore W1885195743C172827444 @default.
• W1885195743 hasConceptScore W1885195743C201853390 @default.
• W1885195743 hasConceptScore W1885195743C2191507 @default.
• W1885195743 hasConceptScore W1885195743C22615655 @default.
• W1885195743 hasConceptScore W1885195743C2779867133 @default.
• W1885195743 hasConceptScore W1885195743C2780102198 @default.
• W1885195743 hasConceptScore W1885195743C54355233 @default.
• W1885195743 hasConceptScore W1885195743C60723119 @default.
• W1885195743 hasConceptScore W1885195743C67705224 @default.
• W1885195743 hasConceptScore W1885195743C86803240 @default.
• W1885195743 hasConceptScore W1885195743C95444343 @default.
• W1885195743 hasLocation W18851957431 @default.

• next