Matches in SemOpenAlex for { <https://semopenalex.org/work/W1885437240> ?p ?o ?g. }
- W1885437240 endingPage "9756" @default.
- W1885437240 startingPage "9751" @default.
- W1885437240 abstract "Significance Huntington’s disease (HD) is a progressive neurodegenerative disorder affecting the striatum. The striatal-enriched transcription factor COUP-TF-interacting protein 2 (Ctip2) is depleted in HD and has been identified as a putative transcription factor for the enzyme inositol polyphosphate multikinase (IPMK). IPMK displays soluble inositol phosphate kinase activity, lipid kinase activity, and several noncatalytic activities including its role as a transcriptional coactivator. We describe severe depletion in IPMK protein in HD patients and several animal and cell models of the disease. IPMK overexpression rescues the metabolic impairments in a cell model of HD. Furthermore, delivery of IPMK in a transgenic HD model improves pathological changes and motor performance. The Ctip2–IPMK–Akt signaling pathway provides a previously unidentified therapeutic target for HD." @default.
- W1885437240 created "2016-06-24" @default.
- W1885437240 creator A5003600685 @default.
- W1885437240 creator A5006367625 @default.
- W1885437240 creator A5007985980 @default.
- W1885437240 creator A5008696550 @default.
- W1885437240 creator A5017969706 @default.
- W1885437240 creator A5020208893 @default.
- W1885437240 creator A5034339736 @default.
- W1885437240 creator A5038199352 @default.
- W1885437240 creator A5042639487 @default.
- W1885437240 creator A5051068492 @default.
- W1885437240 creator A5085559639 @default.
- W1885437240 date "2015-07-20" @default.
- W1885437240 modified "2023-10-16" @default.
- W1885437240 title "Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase" @default.
- W1885437240 cites W1643390591 @default.
- W1885437240 cites W1965247936 @default.
- W1885437240 cites W1972735052 @default.
- W1885437240 cites W1972770584 @default.
- W1885437240 cites W1977383752 @default.
- W1885437240 cites W1990406694 @default.
- W1885437240 cites W1993068285 @default.
- W1885437240 cites W1993844857 @default.
- W1885437240 cites W1993931348 @default.
- W1885437240 cites W1995051993 @default.
- W1885437240 cites W1997555550 @default.
- W1885437240 cites W2002763309 @default.
- W1885437240 cites W2009772352 @default.
- W1885437240 cites W2015714994 @default.
- W1885437240 cites W2025209619 @default.
- W1885437240 cites W2028097766 @default.
- W1885437240 cites W2028716298 @default.
- W1885437240 cites W2035410899 @default.
- W1885437240 cites W2040671431 @default.
- W1885437240 cites W2046122733 @default.
- W1885437240 cites W2048323087 @default.
- W1885437240 cites W2049867157 @default.
- W1885437240 cites W2050852813 @default.
- W1885437240 cites W2053940277 @default.
- W1885437240 cites W2057542247 @default.
- W1885437240 cites W2059801721 @default.
- W1885437240 cites W2062682951 @default.
- W1885437240 cites W2068119597 @default.
- W1885437240 cites W2077886237 @default.
- W1885437240 cites W2081861269 @default.
- W1885437240 cites W2087358641 @default.
- W1885437240 cites W2087826539 @default.
- W1885437240 cites W2089367667 @default.
- W1885437240 cites W2091681614 @default.
- W1885437240 cites W2107522917 @default.
- W1885437240 cites W2114706877 @default.
- W1885437240 cites W2118546680 @default.
- W1885437240 cites W2121642311 @default.
- W1885437240 cites W2123762857 @default.
- W1885437240 cites W2131472300 @default.
- W1885437240 cites W2135306800 @default.
- W1885437240 cites W2135783352 @default.
- W1885437240 cites W2143027879 @default.
- W1885437240 cites W2143912446 @default.
- W1885437240 cites W2144560768 @default.
- W1885437240 cites W2146103593 @default.
- W1885437240 cites W2146267270 @default.
- W1885437240 cites W2146718650 @default.
- W1885437240 cites W2152862617 @default.
- W1885437240 cites W2162760085 @default.
- W1885437240 cites W2162895146 @default.
- W1885437240 cites W2170716497 @default.
- W1885437240 cites W2749718288 @default.
- W1885437240 doi "https://doi.org/10.1073/pnas.1511810112" @default.
- W1885437240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4534278" @default.
- W1885437240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26195796" @default.
- W1885437240 hasPublicationYear "2015" @default.
- W1885437240 type Work @default.
- W1885437240 sameAs 1885437240 @default.
- W1885437240 citedByCount "31" @default.
- W1885437240 countsByYear W18854372402016 @default.
- W1885437240 countsByYear W18854372402017 @default.
- W1885437240 countsByYear W18854372402018 @default.
- W1885437240 countsByYear W18854372402020 @default.
- W1885437240 countsByYear W18854372402021 @default.
- W1885437240 countsByYear W18854372402022 @default.
- W1885437240 countsByYear W18854372402023 @default.
- W1885437240 crossrefType "journal-article" @default.
- W1885437240 hasAuthorship W1885437240A5003600685 @default.
- W1885437240 hasAuthorship W1885437240A5006367625 @default.
- W1885437240 hasAuthorship W1885437240A5007985980 @default.
- W1885437240 hasAuthorship W1885437240A5008696550 @default.
- W1885437240 hasAuthorship W1885437240A5017969706 @default.
- W1885437240 hasAuthorship W1885437240A5020208893 @default.
- W1885437240 hasAuthorship W1885437240A5034339736 @default.
- W1885437240 hasAuthorship W1885437240A5038199352 @default.
- W1885437240 hasAuthorship W1885437240A5042639487 @default.
- W1885437240 hasAuthorship W1885437240A5051068492 @default.
- W1885437240 hasAuthorship W1885437240A5085559639 @default.
- W1885437240 hasBestOaLocation W18854372401 @default.
- W1885437240 hasConcept C104317684 @default.
- W1885437240 hasConcept C126322002 @default.