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- W1885593542 abstract "The inflammasome is a multi-protein complexthat induces maturation of inflammatory cytokines interleukin (IL)-1β and IL-18 through activation of caspase-1. Activation of inflammasome contributes to host defense during diverse bacterial infections. But prolonged activation of inflammasome can be deleterious due to tissue damage associated with chronic inflammatory responses. Cordycepin, a natural compound and adenosine analogue derived from Cordyceps militaris, has been shown to have a great potential for therapeutic use against a number of inflammatory diseases. However, the molecular mechanisms by which cordycepin regulates inflammatory responses have not been clearly elucidated. The aim of this study is to examine the effects of cordycepin on LPS-induced inflammatory response in macrophages and further investigate the underlying molecular mechanisms. Methods Cultured mouse RAW263.4 macrophages and human THP-1-derived macrophages were used in this study. The mRNA and protein levels of caspase-1, IL-1β, IL-6, TNF-α, MCP-1, and COX-2 were detected by real time RT-PCR, ELISA and Western blot, respectively. The activation of NLRP3 inflammasome and ERK was determined by Western blot analysis. Results: Cordycepin significantly inhibited LPS-induced expression of proinflammatory cytokines (IL-1β, IL-6, TNF-α, MCP-1) and COX-2. LPS-mediated NLRP3 and ERK activation was inhibited by cordycepin. Conclusion Cordycepin prevents LPS-induced inflammatory response through influencing NLRP3 inflammasome activation and inhibiting the ERK pathway." @default.
- W1885593542 created "2016-06-24" @default.
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- W1885593542 date "2015-04-01" @default.
- W1885593542 modified "2023-09-25" @default.
- W1885593542 title "Cordycepin Inhibits LPS‐Induced Inflammatory Responses by Modulating NOD‐Like Receptor Protein 3 Inflammasome Activation" @default.
- W1885593542 doi "https://doi.org/10.1096/fasebj.29.1_supplement.715.12" @default.
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