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- W1885679964 abstract "A 49-year-old woman with neuromyelitis optica (NMO) developed severe quadriplegia and frequent paroxysmal tonic spasms (PTS). Carbamazepine, although initially effective against PTS, caused drug eruption and she was unable to continue. PTS re-emerged after discontinuation of carbamazepine and hindered rehabilitation. Then topiramate was started, and PTS promptly disappeared. The patient became able to resume rehabilitation and her activity of daily life improved significantly. Carbamazepine and topiramate have a common pharmacological action to block voltage-gated sodium channels. The action may have contributed to inhibition of ephaptic transmission in the demyelinating lesions by NMO and eventually improved PTS." @default.
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- W1885679964 date "2015-09-01" @default.
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- W1885679964 title "Successful treatment of paroxysmal tonic spasms with topiramate in a patient with neuromyelitis optica" @default.
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- W1885679964 doi "https://doi.org/10.1016/j.msard.2015.07.011" @default.
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