Matches in SemOpenAlex for { <https://semopenalex.org/work/W1885689715> ?p ?o ?g. }
- W1885689715 abstract "Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic. Here we report that CTB binds cell surface glycoproteins. Relative contributions of gangliosides and glycoproteins to CTB binding depend on cell type, and CTB binds primarily to glycoproteins in colonic epithelial cell lines. Using a metabolically incorporated photocrosslinking sugar, we identified one CTB-binding glycoprotein and demonstrated that the glycan portion of the molecule, not the protein, provides the CTB interaction motif. We further show that fucosylated structures promote CTB entry into a colonic epithelial cell line and subsequent host cell intoxication. CTB-binding fucosylated glycoproteins are present in normal human intestinal epithelia and could play a role in cholera." @default.
- W1885689715 created "2016-06-24" @default.
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- W1885689715 date "2015-10-29" @default.
- W1885689715 modified "2023-10-10" @default.
- W1885689715 title "Fucosylation and protein glycosylation create functional receptors for cholera toxin" @default.
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- W1885689715 doi "https://doi.org/10.7554/elife.09545" @default.
- W1885689715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4686427" @default.
- W1885689715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26512888" @default.
- W1885689715 hasPublicationYear "2015" @default.
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