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- W1885912605 endingPage "455S" @default.
- W1885912605 startingPage "447S" @default.
- W1885912605 abstract "In this review, 2 cytokines are discussed with respect to the inflammatory processes that are fundamental to aging and mortality. Both interleukin (IL)-1 and IL-18 are members of the same structural family (IL-1 family, or IL-F); there are presently 9 members of this family, but with the exception of IL-1α, IL-1β, and IL-18, the others are antagonists or remain without known function. IL-1α is an intracellular cytokine with properties of both a cytokine and a transcription factor. IL-1β and IL-18 are closely related; both possess a similar three-dimensional structure, and their respective precursor forms are inactive until cleaved by the intracellular cysteine protease caspase-1. Patients with mutations in the NALP3 gene, which controls the activity of caspase-1, readily secrete more IL-1β and IL-18 and suffer from systemic inflammatory diseases. Patients with defects in this gene have high circulating concentrations of IL-6, serum amyloid A, and C-reactive protein, each of which decrease rapidly upon blockade of the IL-1 receptor, which suggests that IL-1β contributes to the elevation of these markers of the inflammatory mechanisms of aging. Animal studies support the concept that IL-1β and IL-18 participate in the pathogenesis of atherosclerosis. For example, overexpression of the IL-18 binding protein, a naturally occurring, specific inhibitor of IL-18, prevents the spontaneous development of atherosclerosis in apolipoprotein E–deficient mice. From human and animal studies, one may conclude that IL-1β and IL-18 participate in fundamental inflammatory processes that increase during the aging process." @default.
- W1885912605 created "2016-06-24" @default.
- W1885912605 creator A5028234430 @default.
- W1885912605 date "2006-02-01" @default.
- W1885912605 modified "2023-10-12" @default.
- W1885912605 title "Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process" @default.
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