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• W1886205814 endingPage "453" @default.
• W1886205814 startingPage "441" @default.
• W1886205814 abstract "To date, little is known about genes affecting the interplay of brain and heart activity. Because serotonin (5-HT) is involved in corticovagal neurotransmission, we tested whether the 5-HT transporter polymorphism 5-HTTLPR affects brain-heart covariation. Further, associations with neuroticism/anxiety (NANX) were tested, as anxiety is related to 5-HT and neurogenic changes of heart period (HP). N = 168 participants performed a time-estimation task while EEG and HP were recorded. Brain-heart covariation was measured using time-lagged within-subject correlations of centromedial feedback-evoked single-trial EEG at 300 ms and subsequent changes of HP. EEG-HP correlations were higher in 5-HTTLPR long allele carriers. Moreover, after negative feedback, EEG-HP correlations and feedback-related negativity amplitudes independently correlated with NANX. The results indicate that individual differences in brain-heart covariation relate to 5-HT and NANX." @default.
• W1886205814 created "2016-06-24" @default.
• W1886205814 creator A5003144258 @default.
• W1886205814 creator A5034109395 @default.
• W1886205814 creator A5045523172 @default.
• W1886205814 creator A5066369930 @default.
• W1886205814 date "2013-02-27" @default.
• W1886205814 modified "2023-10-07" @default.
• W1886205814 title "<i>5-HTTLPR</i>and anxiety modulate brain-heart covariation" @default.
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• W1886205814 doi "https://doi.org/10.1111/psyp.12016" @default.
• W1886205814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23445439" @default.
• W1886205814 hasPublicationYear "2013" @default.
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