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- W1887021539 abstract "ABSTRACT Microsporidia are obligate intracellular protozoan parasites that cause a wide variety of opportunistic infection in patients with AIDS. Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite. Splenocytes obtained from infected mice proliferate in vitro in response to irradiated parasites. A transient state of hyporesponsiveness to parasite antigen and mitogen was observed at day 17 postinfection. This downregulatory response could be partially reversed by addition of nitric oxide (NO) antagonist to the culture. Mice infected with E. cuniculi secrete significant levels of gamma interferon (IFN-γ). Treatment with antibody to IFN-γ or interleukin-2 (IL-12) was able to neutralize the resistance to the parasite. Mutant animals lacking the IFN-γ or IL-12 gene were highly susceptible to infection. However, mice unable to secrete NO withstood high doses of parasite challenge, similar to normal wild-type animals. These studies describe an IFN-γ-mediated protection against E. cuniculi infection that is independent of NO production." @default.
- W1887021539 created "2016-06-24" @default.
- W1887021539 creator A5040149434 @default.
- W1887021539 creator A5043158260 @default.
- W1887021539 date "1999-04-01" @default.
- W1887021539 modified "2023-10-17" @default.
- W1887021539 title "Role of Gamma Interferon in Cellular Immune Response against Murine <i>Encephalitozoon cuniculi</i> Infection" @default.
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- W1887021539 doi "https://doi.org/10.1128/iai.67.4.1887-1893.1999" @default.
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