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• W1887060892 abstract "Summary Stimulation of E scherichia coli with acetate elevates the acetylation level of the chemotaxis response regulator CheY . This elevation, in an unknown mechanism, activates CheY to generate clockwise rotation. Here, using quantitative selective reaction monitoring mass spectrometry and high‐resolution targeted mass spectrometry, we identified K 91 and K 109 as the major sites whose acetylation level in vivo increases in response to acetate. Employing single and multiple lysine replacements in CheY , we found that K 91 and K 109 are also the sites mainly responsible for acetate‐dependent clockwise generation. Furthermore, we showed that clockwise rotation is repressed when residue K 91 is nonmodified, as evidenced by an increased ability of CheY to generate clockwise rotation when K 91 was acetylated or replaced by specific amino acids. Using molecular dynamics simulations, we show that K 91 repression is manifested in the conformational dynamics of the β4α4 loop, shifted toward an active state upon mutation. Removal of β4α4 loop repression may represent a general activation mechanism in CheY , pertaining also to the canonical phosphorylation activation pathway as suggested by crystal structures of active and inactive CheY from T hermotoga maritima . By way of elimination, we further suggest that K 109 acetylation is actively involved in generating clockwise rotation." @default.
• W1887060892 created "2016-06-24" @default.
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• W1887060892 date "2014-12-08" @default.
• W1887060892 modified "2023-10-03" @default.
• W1887060892 title "CheY's acetylation sites responsible for generating clockwise flagellar rotation in<i>E</i><i>scherichia coli</i>" @default.
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• W1887060892 doi "https://doi.org/10.1111/mmi.12858" @default.
• W1887060892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4426874" @default.
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