Matches in SemOpenAlex for { <https://semopenalex.org/work/W188713852> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W188713852 abstract "Background: Glucocorticoids have a wide-range of beneficial effects for treating inflammatory, allergic, and immunologic conditions. However, glucocorticoid therapy can lead to increased bone resorption and reduced bone formation by inhibiting osteoblast proliferation. This bone deterioration leads to osteoporosis. When considering therapy for prevention of fractures in glucocorticoid-induced osteoporosis (GIO), teriparatide (recombinant human parathyroid hormone 1-34) is an anabolic agent that can be used to improve bone mineral density (BMD) and prevent fractures. Due to bone deterioration caused by glucocorticoid therapy, prevention of bone fractures has significant importance. While there are several choices for therapy for prevention of GIO, the anabolic agent teriparatide could show a more significant improvement of BMD and of preventing fractures resulting from GIO. The purpose of this systematic review of the literature is to evaluate the efficacy of teriparatide in prevention of fractures that can result from glucocorticoid therapy. Methods: An extensive literature search was conducted using Medline-OVID, CINAHL, Evidence Based Medicine Reviews Multifile, and Web of Science using the search terms: teriparatide, osteoporosis, fractures, and glucocorticoids. The reference sections of each of these articles were further searched for additional relevant sources. Articles were screened and evaluated for relevance using GRADE. Results: Two studies met inclusion criteria for this systematic review that included two randomized control trials. These studies demonstrated that patients who were on teriparatide had increased BMD. Both studies also measured fracture rates and showed a decrease favoring teriparatide. Conclusion: There is sufficient evidence to recommend teriparatide as a therapeutic option for reversing the effects of glucocorticoid-induced osteoporosis by improving bone mineral density and preventing the occurrence of fractures, although there may still remain a question of safety that would warrant continued research." @default.
- W188713852 created "2016-06-24" @default.
- W188713852 creator A5040425108 @default.
- W188713852 date "2013-01-01" @default.
- W188713852 modified "2023-09-27" @default.
- W188713852 title "Effectiveness of Teriparatide Therapy for Prevention of Fractures in Glucocorticoid-Induced Osteoporosis" @default.
- W188713852 cites W1554395215 @default.
- W188713852 cites W1983391342 @default.
- W188713852 cites W1992310701 @default.
- W188713852 cites W1993961484 @default.
- W188713852 cites W2028192162 @default.
- W188713852 cites W2042007405 @default.
- W188713852 cites W2101680622 @default.
- W188713852 cites W2106145280 @default.
- W188713852 cites W2127733654 @default.
- W188713852 cites W2139072521 @default.
- W188713852 cites W2140470606 @default.
- W188713852 cites W2164733079 @default.
- W188713852 cites W2419631879 @default.
- W188713852 hasPublicationYear "2013" @default.
- W188713852 type Work @default.
- W188713852 sameAs 188713852 @default.
- W188713852 citedByCount "0" @default.
- W188713852 crossrefType "journal-article" @default.
- W188713852 hasAuthorship W188713852A5040425108 @default.
- W188713852 hasConcept C118552586 @default.
- W188713852 hasConcept C126322002 @default.
- W188713852 hasConcept C134018914 @default.
- W188713852 hasConcept C168563851 @default.
- W188713852 hasConcept C27415008 @default.
- W188713852 hasConcept C2776541429 @default.
- W188713852 hasConcept C2776886416 @default.
- W188713852 hasConcept C2777308945 @default.
- W188713852 hasConcept C2780841215 @default.
- W188713852 hasConcept C2781145037 @default.
- W188713852 hasConcept C2911223091 @default.
- W188713852 hasConcept C71924100 @default.
- W188713852 hasConceptScore W188713852C118552586 @default.
- W188713852 hasConceptScore W188713852C126322002 @default.
- W188713852 hasConceptScore W188713852C134018914 @default.
- W188713852 hasConceptScore W188713852C168563851 @default.
- W188713852 hasConceptScore W188713852C27415008 @default.
- W188713852 hasConceptScore W188713852C2776541429 @default.
- W188713852 hasConceptScore W188713852C2776886416 @default.
- W188713852 hasConceptScore W188713852C2777308945 @default.
- W188713852 hasConceptScore W188713852C2780841215 @default.
- W188713852 hasConceptScore W188713852C2781145037 @default.
- W188713852 hasConceptScore W188713852C2911223091 @default.
- W188713852 hasConceptScore W188713852C71924100 @default.
- W188713852 hasLocation W1887138521 @default.
- W188713852 hasOpenAccess W188713852 @default.
- W188713852 hasPrimaryLocation W1887138521 @default.
- W188713852 hasRelatedWork W115663059 @default.
- W188713852 hasRelatedWork W1217114663 @default.
- W188713852 hasRelatedWork W1824311463 @default.
- W188713852 hasRelatedWork W2001924322 @default.
- W188713852 hasRelatedWork W2046599765 @default.
- W188713852 hasRelatedWork W2071350501 @default.
- W188713852 hasRelatedWork W2087613249 @default.
- W188713852 hasRelatedWork W2158780196 @default.
- W188713852 hasRelatedWork W2402209974 @default.
- W188713852 hasRelatedWork W2403043103 @default.
- W188713852 hasRelatedWork W2419290049 @default.
- W188713852 hasRelatedWork W2489703903 @default.
- W188713852 hasRelatedWork W2726184882 @default.
- W188713852 hasRelatedWork W2801971271 @default.
- W188713852 hasRelatedWork W2853926851 @default.
- W188713852 hasRelatedWork W3012208209 @default.
- W188713852 hasRelatedWork W3097711741 @default.
- W188713852 hasRelatedWork W3167611244 @default.
- W188713852 hasRelatedWork W169043795 @default.
- W188713852 hasRelatedWork W2400084203 @default.
- W188713852 isParatext "false" @default.
- W188713852 isRetracted "false" @default.
- W188713852 magId "188713852" @default.
- W188713852 workType "article" @default.