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- W1887283934 abstract "The Renin Angiotensin system has been implicated in the pathogenesis of Drug Induced Gingival Overgrowth (DIGO), a fibrotic condition, caused by Phenytoin, Nifedipine and Cyclosporine.This study quantified Angiotensin II levels in gingival tissue samples obtained from healthy individuals, patients on Nifedipine manifesting/not manifesting drug induced gingival overgrowth.Gingival tissue samples were obtained from healthy individuals (n=24), patients on nifidipine manifesting gingival overgrowth (n= 18) and patients on nifidipine not manifesting gingival overgrowth (n=8). Angiotensin II levels were estimated in the samples using a commercially available ELISA kit.Angiotensin II levels were significantly elevated in patients on Nifedipine manifesting gingival overgrowth compared to the other 2 groups (p<0.01).The results of the study give an insight into the role played by Angiotensin II in the pathogenesis of drug induced gingival overgrowth." @default.
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- W1887283934 date "2015-01-01" @default.
- W1887283934 modified "2023-10-16" @default.
- W1887283934 title "Angiotensin II Levels in Gingival Tissues from Healthy Individuals, Patients with Nifedipine Induced Gingival Overgrowth and Non Responders on Nifedipine" @default.
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- W1887283934 doi "https://doi.org/10.7860/jcdr/2015/14492.6388" @default.
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