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• W1887461194 endingPage "56" @default.
• W1887461194 startingPage "43" @default.
• W1887461194 abstract "Abstract Tandem inverted repeats (TIRs or hairpins) of 30 and 80 base-pair unit lengths are unstable mitotically in yeast (Saccharomyces cerevisiae). TIR instability results from deletions that remove part or all of the presumed hairpin structure from the chromosome. At least one deletion endpoint is always at or near the base of the hairpin, and almost all of the repaired junctions occur within short direct sequence repeats of 4 to 9 base pairs. The frequency of this event, which we call hairpin excision, is influenced by chromosomal position, length of the inverted repeats, and the distance separating the repeat units; increasing the distance between the inverted repeats as little as 25 base pairs increases their chromosomal stability. The frequency of excision is not affected by representative rad mutations, but is influenced by mutations in certain genes affecting DNA synthesis. In particular, mutations in POL1/CDC17, the gene that encodes the large subunit of DNA polymerase I, increase the frequency of hairpin deletions significantly, implicating this protein in the normal maintainance of genomic TIRs." @default.
• W1887461194 created "2016-06-24" @default.
• W1887461194 creator A5040152823 @default.
• W1887461194 creator A5060182437 @default.
• W1887461194 date "1993-05-01" @default.
• W1887461194 modified "2023-09-27" @default.
• W1887461194 title "Mutations in POL1 increase the mitotic instability of tandem inverted repeats in Saccharomyces cerevisiae." @default.
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• W1887461194 doi "https://doi.org/10.1093/genetics/134.1.43" @default.
• W1887461194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1205442" @default.
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• W1887461194 hasPublicationYear "1993" @default.
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