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- W188772675 abstract "The aim of the work described in this thesis was to investigate the value ofconventional, perfusion- and diffusion-weighted magnetic resonance imaging (MRI)in patients with histology-proven low-grade gliomas (LGG), and the potential role ofthese methods in the management of patients with these brain tumours.Thirty-six patients were studied at the National Hospital for Neurology andNeurosurgery using conventional, perfusion-weighted and diffusion-weighted MRIat study entry and 6 monthly intervals thereafter. At each visit, tumour volume,maximum rCBV and ADC histogram measures were calculated. This is a uniquecohort, as patients were treatment free until malignant transformation was diagnosed,which translates the natural history of these brain tumours. It is unlikely to find sucha specific cohort as most of the patients receive treatment after the initial diagnosisof low grade gliomas.Chapters 1 and 2 of this thesis describe the theoretical basis of the MRI techniquesused, and summarise the natural history and imaging aspects of cerebral gliomas.Chapter 3 describes a methodological study relating to tumour perfusionmeasurement: since the inclusion or exclusion of intratumoural vessels mayinfluence the quantification of relative cerebral blood volume (rCBV), a study wasconducted to choose the best ROI placement technique to be used for the rCBVmeasurements included in this thesis. It was shown that only the approach whichexcluded intratumoural vessels demonstrated a significant association between rCBVvalues and tumour subtypes (astrocytomas, oligodendrogliomas andoligoastrocytomas) and therefore this technique was used in all subsequent rCBVmeasurements." @default.
- W188772675 created "2016-06-24" @default.
- W188772675 creator A5061303717 @default.
- W188772675 date "2008-12-01" @default.
- W188772675 modified "2023-09-25" @default.
- W188772675 title "The use of conventional and advanced magnetic resonance techniques in the assessment of primary brain tumours" @default.
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