FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1887768293> ?p ?o ?g. }

• W1887768293 endingPage "372" @default.
• W1887768293 startingPage "364" @default.
• W1887768293 abstract "In early embryos, the DNA damage checkpoint is silent until the midblastula transition (MBT) because of maternal limiting factors of unknown identity. Here we identify the RAD18 ubiquitin ligase as one such factor in Xenopus. We show, in vitro and in vivo, that inactivation of RAD18 function leads to DNA damage-dependent checkpoint activation, monitored by CHK1 phosphorylation. Moreover, we show that the abundance of both RAD18 and PCNA monoubiquitylated (mUb) are developmentally regulated. Increased DNA abundance limits the availability of RAD18 close to the MBT, thereby reducing PCNAmUb and inducing checkpoint derepression. Furthermore, we show that this embryonic-like regulation can be reactivated in somatic mammalian cells by ectopic RAD18 expression, therefore conferring resistance to DNA damage. Finally, we find high RAD18 expression in cancer stem cells highly resistant to DNA damage. Together, these data propose RAD18 as a critical embryonic checkpoint-inhibiting factor and suggest that RAD18 deregulation may have unexpected oncogenic potential." @default.
• W1887768293 created "2016-06-24" @default.
• W1887768293 creator A5017346800 @default.
• W1887768293 creator A5020030350 @default.
• W1887768293 creator A5050654911 @default.
• W1887768293 creator A5060432507 @default.
• W1887768293 creator A5060829795 @default.
• W1887768293 creator A5066953772 @default.
• W1887768293 creator A5075378844 @default.
• W1887768293 creator A5090064508 @default.
• W1887768293 date "2015-08-01" @default.
• W1887768293 modified "2023-10-16" @default.
• W1887768293 title "RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos" @default.
• W1887768293 cites W1965768718 @default.
• W1887768293 cites W1969321207 @default.
• W1887768293 cites W1974394081 @default.
• W1887768293 cites W1978982015 @default.
• W1887768293 cites W1980745500 @default.
• W1887768293 cites W1984320346 @default.
• W1887768293 cites W1988745695 @default.
• W1887768293 cites W1992705983 @default.
• W1887768293 cites W2001609760 @default.
• W1887768293 cites W2014993354 @default.
• W1887768293 cites W2020754261 @default.
• W1887768293 cites W2027733273 @default.
• W1887768293 cites W2029369774 @default.
• W1887768293 cites W2029956405 @default.
• W1887768293 cites W2032586308 @default.
• W1887768293 cites W2043046511 @default.
• W1887768293 cites W2055521166 @default.
• W1887768293 cites W2066605687 @default.
• W1887768293 cites W2069312900 @default.
• W1887768293 cites W2080574942 @default.
• W1887768293 cites W2086896040 @default.
• W1887768293 cites W2089340936 @default.
• W1887768293 cites W2093984973 @default.
• W1887768293 cites W2097824787 @default.
• W1887768293 cites W2099607402 @default.
• W1887768293 cites W2101101375 @default.
• W1887768293 cites W2105513499 @default.
• W1887768293 cites W2120275505 @default.
• W1887768293 cites W2121950243 @default.
• W1887768293 cites W2122020699 @default.
• W1887768293 cites W2124929852 @default.
• W1887768293 cites W2127613597 @default.
• W1887768293 cites W2127849733 @default.
• W1887768293 cites W2128275272 @default.
• W1887768293 cites W2136438090 @default.
• W1887768293 cites W2141115493 @default.
• W1887768293 cites W2159057522 @default.
• W1887768293 cites W935855719 @default.
• W1887768293 doi "https://doi.org/10.1016/j.devcel.2015.06.002" @default.
• W1887768293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26212134" @default.
• W1887768293 hasPublicationYear "2015" @default.
• W1887768293 type Work @default.
• W1887768293 sameAs 1887768293 @default.
• W1887768293 citedByCount "28" @default.
• W1887768293 countsByYear W18877682932016 @default.
• W1887768293 countsByYear W18877682932017 @default.
• W1887768293 countsByYear W18877682932018 @default.
• W1887768293 countsByYear W18877682932019 @default.
• W1887768293 countsByYear W18877682932020 @default.
• W1887768293 countsByYear W18877682932021 @default.
• W1887768293 countsByYear W18877682932022 @default.
• W1887768293 countsByYear W18877682932023 @default.
• W1887768293 crossrefType "journal-article" @default.
• W1887768293 hasAuthorship W1887768293A5017346800 @default.
• W1887768293 hasAuthorship W1887768293A5020030350 @default.
• W1887768293 hasAuthorship W1887768293A5050654911 @default.
• W1887768293 hasAuthorship W1887768293A5060432507 @default.
• W1887768293 hasAuthorship W1887768293A5060829795 @default.
• W1887768293 hasAuthorship W1887768293A5066953772 @default.
• W1887768293 hasAuthorship W1887768293A5075378844 @default.
• W1887768293 hasAuthorship W1887768293A5090064508 @default.
• W1887768293 hasBestOaLocation W18877682931 @default.
• W1887768293 hasConcept C104317684 @default.
• W1887768293 hasConcept C105696609 @default.
• W1887768293 hasConcept C134459356 @default.
• W1887768293 hasConcept C143425029 @default.
• W1887768293 hasConcept C153911025 @default.
• W1887768293 hasConcept C190283241 @default.
• W1887768293 hasConcept C25602115 @default.
• W1887768293 hasConcept C2779535977 @default.
• W1887768293 hasConcept C29537977 @default.
• W1887768293 hasConcept C34688535 @default.
• W1887768293 hasConcept C50001416 @default.
• W1887768293 hasConcept C54086632 @default.
• W1887768293 hasConcept C54355233 @default.
• W1887768293 hasConcept C552990157 @default.
• W1887768293 hasConcept C81885089 @default.
• W1887768293 hasConcept C86803240 @default.
• W1887768293 hasConcept C95444343 @default.
• W1887768293 hasConcept C97037327 @default.
• W1887768293 hasConceptScore W1887768293C104317684 @default.
• W1887768293 hasConceptScore W1887768293C105696609 @default.
• W1887768293 hasConceptScore W1887768293C134459356 @default.
• W1887768293 hasConceptScore W1887768293C143425029 @default.
• W1887768293 hasConceptScore W1887768293C153911025 @default.

• next