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- W188783487 abstract "Publisher Summary This chapter presents experiments to illustrate that B cells of adult CBA mice are made up of at least two sub-populations. One of these is thymus independent and it responds to sheep red blood cells without much T cell help and in addition can become tolerant to sheep cells without T cell help. After it is made tolerant to SRBC, T cell help does not break its unresponsive state. A second population fails to react to sheep cells without T cell help, either to become immune or tolerant. Induction of tolerance in the first population does not detectably alter the response of the second, indicating the two cells may come from separate lines. In addition, sheep red blood cell stimulated T cells can make, or cause to be made, factors that render other T cells specifically unresponsive to sheep cells. Whether this factor also acts on B cells is not clear. If it does, it does so at much higher thresholds. Antigen-stimulated T cells can also make, or cause to be made, factors that render other T cells refractory to, or at least increase the threshold requirements for, the suppressive signal. The latter factor has less antigen specificity than the former." @default.
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- W188783487 date "1974-01-01" @default.
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- W188783487 title "LACK OF ACTIVITY OF CONTRA-SUPPRESSOR T CELLS AS A MECHANISM OF TOLERANCE" @default.
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- W188783487 doi "https://doi.org/10.1016/b978-0-12-401650-7.50044-2" @default.
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