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• W1887878037 endingPage "3364" @default.
• W1887878037 startingPage "3355" @default.
• W1887878037 abstract "An AU-rich sequence present within the 3' untranslated region has been shown to mark some short-lived mRNAs for rapid degradation. We demonstrate by label transfer and gel shift experiments that a 32-kDa polypeptide, present in nuclear extracts, specifically interacts with the AU-rich domains present within the 3' untranslated region of human granulocyte-macrophage colony-stimulating factor, c-fos, and c-myc mRNAs and a similar domain downstream of the poly(A) addition site of the adenovirus IVa2 mRNA. Competition experiments and partial protease analysis indicated that the same polypeptide interacts with all four RNAs. A single AUUUA sequence in a U-rich context was sufficient to signal binding of the 32-kDa polypeptide. Insertion of three copies of this minimal recognition site led to markedly reduced accumulation of beta-globin RNA, while the same insert carrying a series of U-to-G changes had little effect on RNA levels. Steady-state levels of beta-globin-specific nuclear RNA, including incompletely processed RNA, and cytoplasmic mRNA were reduced. Cytoplasmic mRNA containing the AU-rich recognition sites for the 32-kDa polypeptide exhibited a half-life shorter than that of mRNA with a mutated insert. We suggest that binding of the 32-kDa polypeptide may be involved in the regulation of mRNA half-life." @default.
• W1887878037 created "2016-06-24" @default.
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• W1887878037 date "1991-06-01" @default.
• W1887878037 modified "2023-10-12" @default.
• W1887878037 title "A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs." @default.
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• W1887878037 doi "https://doi.org/10.1128/mcb.11.6.3355" @default.
• W1887878037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/360189" @default.
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• W1887878037 hasPublicationYear "1991" @default.
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