Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888057007> ?p ?o ?g. }
- W1888057007 endingPage "3146" @default.
- W1888057007 startingPage "3139" @default.
- W1888057007 abstract "The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify and characterize novel FGFR2 extracellular domain insertion mutations and demonstrate that they are both oncogenic and sensitive to inhibition by FGFR kinase inhibitors. We demonstrate that the mechanism of FGFR2 activation and subsequent transformation is mediated by ligand-independent dimerization and activation of FGFR2 kinase activity. Both FGFR2-mutant forms are predominantly located in the endoplasmic reticulum and Golgi but nevertheless can activate downstream signaling pathways through their interactions with fibroblast growth factor receptor substrate 2 (FRS2). Our findings provide a rationale for therapeutically targeting this unique subset of FGFR2-mutant cancers as well as insight into their oncogenic mechanisms." @default.
- W1888057007 created "2016-06-24" @default.
- W1888057007 creator A5003183589 @default.
- W1888057007 creator A5004171995 @default.
- W1888057007 creator A5009037819 @default.
- W1888057007 creator A5017518259 @default.
- W1888057007 creator A5019034689 @default.
- W1888057007 creator A5028909262 @default.
- W1888057007 creator A5042026464 @default.
- W1888057007 creator A5042281153 @default.
- W1888057007 creator A5045665778 @default.
- W1888057007 creator A5048675362 @default.
- W1888057007 creator A5076568893 @default.
- W1888057007 creator A5076878417 @default.
- W1888057007 creator A5090452503 @default.
- W1888057007 creator A5090956629 @default.
- W1888057007 date "2015-08-01" @default.
- W1888057007 modified "2023-10-17" @default.
- W1888057007 title "Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2" @default.
- W1888057007 cites W1563019250 @default.
- W1888057007 cites W1588963749 @default.
- W1888057007 cites W1975784282 @default.
- W1888057007 cites W1977817878 @default.
- W1888057007 cites W1981275452 @default.
- W1888057007 cites W1981734567 @default.
- W1888057007 cites W1989344307 @default.
- W1888057007 cites W2004893350 @default.
- W1888057007 cites W2005036868 @default.
- W1888057007 cites W2018336040 @default.
- W1888057007 cites W2027770279 @default.
- W1888057007 cites W2039094650 @default.
- W1888057007 cites W2043696829 @default.
- W1888057007 cites W2044293524 @default.
- W1888057007 cites W2069800089 @default.
- W1888057007 cites W2075790601 @default.
- W1888057007 cites W2081855695 @default.
- W1888057007 cites W2095046027 @default.
- W1888057007 cites W2099530756 @default.
- W1888057007 cites W2107977954 @default.
- W1888057007 cites W2108939654 @default.
- W1888057007 cites W2123080551 @default.
- W1888057007 cites W2126298634 @default.
- W1888057007 cites W2127919472 @default.
- W1888057007 cites W2127990562 @default.
- W1888057007 cites W2130940380 @default.
- W1888057007 cites W2133963438 @default.
- W1888057007 cites W2136549416 @default.
- W1888057007 cites W2155413391 @default.
- W1888057007 cites W2159060826 @default.
- W1888057007 cites W2160981405 @default.
- W1888057007 cites W2164185692 @default.
- W1888057007 doi "https://doi.org/10.1158/0008-5472.can-14-3771" @default.
- W1888057007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26048680" @default.
- W1888057007 hasPublicationYear "2015" @default.
- W1888057007 type Work @default.
- W1888057007 sameAs 1888057007 @default.
- W1888057007 citedByCount "30" @default.
- W1888057007 countsByYear W18880570072016 @default.
- W1888057007 countsByYear W18880570072017 @default.
- W1888057007 countsByYear W18880570072018 @default.
- W1888057007 countsByYear W18880570072019 @default.
- W1888057007 countsByYear W18880570072020 @default.
- W1888057007 countsByYear W18880570072021 @default.
- W1888057007 countsByYear W18880570072022 @default.
- W1888057007 crossrefType "journal-article" @default.
- W1888057007 hasAuthorship W1888057007A5003183589 @default.
- W1888057007 hasAuthorship W1888057007A5004171995 @default.
- W1888057007 hasAuthorship W1888057007A5009037819 @default.
- W1888057007 hasAuthorship W1888057007A5017518259 @default.
- W1888057007 hasAuthorship W1888057007A5019034689 @default.
- W1888057007 hasAuthorship W1888057007A5028909262 @default.
- W1888057007 hasAuthorship W1888057007A5042026464 @default.
- W1888057007 hasAuthorship W1888057007A5042281153 @default.
- W1888057007 hasAuthorship W1888057007A5045665778 @default.
- W1888057007 hasAuthorship W1888057007A5048675362 @default.
- W1888057007 hasAuthorship W1888057007A5076568893 @default.
- W1888057007 hasAuthorship W1888057007A5076878417 @default.
- W1888057007 hasAuthorship W1888057007A5090452503 @default.
- W1888057007 hasAuthorship W1888057007A5090956629 @default.
- W1888057007 hasBestOaLocation W18880570072 @default.
- W1888057007 hasConcept C104317684 @default.
- W1888057007 hasConcept C119062480 @default.
- W1888057007 hasConcept C121608353 @default.
- W1888057007 hasConcept C143065580 @default.
- W1888057007 hasConcept C158617107 @default.
- W1888057007 hasConcept C170493617 @default.
- W1888057007 hasConcept C184235292 @default.
- W1888057007 hasConcept C2781230642 @default.
- W1888057007 hasConcept C28406088 @default.
- W1888057007 hasConcept C32619005 @default.
- W1888057007 hasConcept C50044444 @default.
- W1888057007 hasConcept C501734568 @default.
- W1888057007 hasConcept C502942594 @default.
- W1888057007 hasConcept C54355233 @default.
- W1888057007 hasConcept C62478195 @default.
- W1888057007 hasConcept C74373430 @default.
- W1888057007 hasConcept C82867764 @default.
- W1888057007 hasConcept C86803240 @default.