FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888147939> ?p ?o ?g. }

• W1888147939 endingPage "64" @default.
• W1888147939 startingPage "57" @default.
• W1888147939 abstract "We have determined the dose-response curves (100-900 mg of Fe/kg body wt.) and the time course over 84 days for the effects of a single injection of iron-dextran on rat hepatic 5-aminolaevulinate synthetase, cytochrome P-450, iron content, and GSH (reduced glutathione). Porphyrins in liver and urine have also been measured. (1) At 2 days after treatment, a dose of 500 mg of Fe/kg produced a 20-fold increase in iron concentration, which was maintained for 14 days. Total hepatic iron remained constant over 63 days, falling slightly by 84 days. (2) The activity of 5-aminolaevulinate synthetase was maximally increased (6-fold) 12-24 h after iron treatment. By 48 h the activity fell to less than twice the control value and thereafter remained slightly above the control value (1.1-1.5-fold) until 84 days after iron treatment. Liver GSH concentrations were unaffected by iron. Porphyrins in liver and urine were either unchanged or decreased. (3) Hepatic cytochrome P-450 decreased after iron treatment to a minimum (63% of control) at 48 h after iron administration and gradually returned to the control value by 28 days. (4) Iron-dextran potentiated 2 allyl-2-isopropyl-acetamide-induced synthesis of hepatic 5-aminolaevulinate. Potentiation occurred if the drug was given at the same time or 36 h after iron administration, but did not occur if the drug was given 14 or 64 days after iron administration. (5) The results are discussed in relation to proposed mechanisms for the effects of iron on hepatic haem metabolism." @default.
• W1888147939 created "2016-06-24" @default.
• W1888147939 creator A5013298828 @default.
• W1888147939 creator A5031228335 @default.
• W1888147939 creator A5032404713 @default.
• W1888147939 creator A5063888838 @default.
• W1888147939 creator A5088160115 @default.
• W1888147939 date "1981-04-15" @default.
• W1888147939 modified "2023-10-16" @default.
• W1888147939 title "Iron and the liver Acute and long-term effects of iron-loading on hepatic haem metabolism" @default.
• W1888147939 cites W117204598 @default.
• W1888147939 cites W1591909631 @default.
• W1888147939 cites W1598667621 @default.
• W1888147939 cites W1603000972 @default.
• W1888147939 cites W1878915947 @default.
• W1888147939 cites W1941284035 @default.
• W1888147939 cites W1951469402 @default.
• W1888147939 cites W1987371201 @default.
• W1888147939 cites W1996146940 @default.
• W1888147939 cites W2001503084 @default.
• W1888147939 cites W2006433745 @default.
• W1888147939 cites W2019003542 @default.
• W1888147939 cites W2021058149 @default.
• W1888147939 cites W2026261400 @default.
• W1888147939 cites W2034442998 @default.
• W1888147939 cites W2034954980 @default.
• W1888147939 cites W2080597450 @default.
• W1888147939 cites W2083038669 @default.
• W1888147939 cites W2084257956 @default.
• W1888147939 cites W2094253672 @default.
• W1888147939 cites W2286737700 @default.
• W1888147939 cites W2337209710 @default.
• W1888147939 cites W2340037228 @default.
• W1888147939 cites W2346379043 @default.
• W1888147939 cites W2403420775 @default.
• W1888147939 cites W2404707360 @default.
• W1888147939 cites W2409296026 @default.
• W1888147939 cites W2418890389 @default.
• W1888147939 cites W347769072 @default.
• W1888147939 cites W82466380 @default.
• W1888147939 doi "https://doi.org/10.1042/bj1960057" @default.
• W1888147939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1162967" @default.
• W1888147939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7306080" @default.
• W1888147939 hasPublicationYear "1981" @default.
• W1888147939 type Work @default.
• W1888147939 sameAs 1888147939 @default.
• W1888147939 citedByCount "64" @default.
• W1888147939 countsByYear W18881479392012 @default.
• W1888147939 countsByYear W18881479392013 @default.
• W1888147939 countsByYear W18881479392014 @default.
• W1888147939 countsByYear W18881479392015 @default.
• W1888147939 countsByYear W18881479392017 @default.
• W1888147939 countsByYear W18881479392018 @default.
• W1888147939 countsByYear W18881479392019 @default.
• W1888147939 countsByYear W18881479392021 @default.
• W1888147939 crossrefType "journal-article" @default.
• W1888147939 hasAuthorship W1888147939A5013298828 @default.
• W1888147939 hasAuthorship W1888147939A5031228335 @default.
• W1888147939 hasAuthorship W1888147939A5032404713 @default.
• W1888147939 hasAuthorship W1888147939A5063888838 @default.
• W1888147939 hasAuthorship W1888147939A5088160115 @default.
• W1888147939 hasBestOaLocation W18881479392 @default.
• W1888147939 hasConcept C126322002 @default.
• W1888147939 hasConcept C134018914 @default.
• W1888147939 hasConcept C181199279 @default.
• W1888147939 hasConcept C185592680 @default.
• W1888147939 hasConcept C2780768313 @default.
• W1888147939 hasConcept C538909803 @default.
• W1888147939 hasConcept C55493867 @default.
• W1888147939 hasConcept C62231903 @default.
• W1888147939 hasConcept C71924100 @default.
• W1888147939 hasConcept C86803240 @default.
• W1888147939 hasConcept C89311334 @default.
• W1888147939 hasConceptScore W1888147939C126322002 @default.
• W1888147939 hasConceptScore W1888147939C134018914 @default.
• W1888147939 hasConceptScore W1888147939C181199279 @default.
• W1888147939 hasConceptScore W1888147939C185592680 @default.
• W1888147939 hasConceptScore W1888147939C2780768313 @default.
• W1888147939 hasConceptScore W1888147939C538909803 @default.
• W1888147939 hasConceptScore W1888147939C55493867 @default.
• W1888147939 hasConceptScore W1888147939C62231903 @default.
• W1888147939 hasConceptScore W1888147939C71924100 @default.
• W1888147939 hasConceptScore W1888147939C86803240 @default.
• W1888147939 hasConceptScore W1888147939C89311334 @default.
• W1888147939 hasIssue "1" @default.
• W1888147939 hasLocation W18881479391 @default.
• W1888147939 hasLocation W18881479392 @default.
• W1888147939 hasLocation W18881479393 @default.
• W1888147939 hasLocation W18881479394 @default.
• W1888147939 hasOpenAccess W1888147939 @default.
• W1888147939 hasPrimaryLocation W18881479391 @default.
• W1888147939 hasRelatedWork W1967571756 @default.
• W1888147939 hasRelatedWork W2034712323 @default.
• W1888147939 hasRelatedWork W2047764430 @default.
• W1888147939 hasRelatedWork W2278836224 @default.
• W1888147939 hasRelatedWork W2395738650 @default.
• W1888147939 hasRelatedWork W2408811643 @default.
• W1888147939 hasRelatedWork W2411440469 @default.

• next