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- W1888261674 abstract "Abstract The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers located distally from the promoter with respect to the position of the su(Hw)-binding region. Mutations in a second gene, modifier of mdg4, also affect the gypsy-induced phenotype. Two major effects of the mod(mdg4)lul mutation can be distinguished: the interference with insulation by the su(Hw)-binding region and direct inhibition of gene expression that is not dependent on the su(Hw)-binding region position. The mod(mdg4)lul mutation partially suppresses ct6, scD1 and Hw1 mutations, possibly by interfering with the insulation effect of the su(Hw)-binding region. An example of the second effect of mod(mdg4)lul is a complete inactivation of yellow expression in combination with the y 2 allele. Phenotypic analyses of flies with combinations of mod(mdg4)lul and different su(Hw) mutations, or with constructions carrying deletions of the acidic domains of the su(Hw) protein, suggest that the carboxy-terminal acidic domain is important for direct inhibition of yellow transcription in bristles, while the amino-terminal acidic domain is more essential for insulation." @default.
- W1888261674 created "2016-06-24" @default.
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- W1888261674 date "1996-02-01" @default.
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- W1888261674 title "Interaction Between Mutations in the <i>suppressor of Hairy wing</i> and <i>modifier of mdg4</i> Genes of <i>Drosophila melunogaster</i> Affecting the Phenotype of <i>gypsy</i>-Induced Mutations" @default.
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- W1888261674 doi "https://doi.org/10.1093/genetics/142.2.425" @default.
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