Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888297727> ?p ?o ?g. }
- W1888297727 endingPage "70" @default.
- W1888297727 startingPage "59" @default.
- W1888297727 abstract "Abstract Double-strand break (DSB) induced gene conversion in Saccharomyces cerevisiae during meiosis and MAT switching is mediated primarily by mismatch repair of heteroduplex DNA (hDNA). We used nontandem ura3 duplications containing palindromic frameshift insertion mutations near an HO nuclease recognition site to test whether mismatch repair also mediates DSB-induced mitotic gene conversion at a non-MAT locus. Palindromic insertions included in hDNA are expected to produce a stem-loop mismatch, escape repair, and segregate to produce a sectored (Ura+/−) colony. If conversion occurs by gap repair, the insertion should be removed on both strands, and converted colonies will not be sectored. For both a 14-bp palindrome, and a 37-bp near-palindrome, ~75% of recombinant colonies were sectored, indicating that most DSB-induced mitotic gene conversion involves mismatch repair of hDNA. We also investigated mismatch repair of well-repaired markers flanking an unrepaired palindrome. As seen in previous studies, these additional markers increased loop repair (likely reflecting corepair). Among sectored products, few had additional segregating markers, indicating that the lack of repair at one marker is not associated with inefficient repair at nearby markers. Clear evidence was obtained for low levels of short tract mismatch repair. As seen with full gene conversions, donor alleles in sectored products were not altered. Markers on the same side of the DSB as the palindrome were involved in hDNA less often among sectored products than nonsectored products, but markers on the opposite side of the DSB showed similar hDNA involvement among both product classes. These results can be explained in terms of corepair, and they suggest that mismatch repair on opposite sides of a DSB involves distinct repair tracts." @default.
- W1888297727 created "2016-06-24" @default.
- W1888297727 creator A5046719549 @default.
- W1888297727 creator A5054332041 @default.
- W1888297727 date "1998-01-01" @default.
- W1888297727 modified "2023-09-24" @default.
- W1888297727 title "Evidence for Independent Mismatch Repair Processing on Opposite Sides of a Double-Strand Break in Saccharomyces cerevisiae" @default.
- W1888297727 cites W109338624 @default.
- W1888297727 cites W121224471 @default.
- W1888297727 cites W1488992604 @default.
- W1888297727 cites W1753994516 @default.
- W1888297727 cites W1787998249 @default.
- W1888297727 cites W1841252158 @default.
- W1888297727 cites W1848421747 @default.
- W1888297727 cites W1855000980 @default.
- W1888297727 cites W1869600472 @default.
- W1888297727 cites W1906085132 @default.
- W1888297727 cites W1908056424 @default.
- W1888297727 cites W1938689952 @default.
- W1888297727 cites W1949150282 @default.
- W1888297727 cites W1966608028 @default.
- W1888297727 cites W1967888902 @default.
- W1888297727 cites W1973778656 @default.
- W1888297727 cites W1974141537 @default.
- W1888297727 cites W1983727450 @default.
- W1888297727 cites W1985910275 @default.
- W1888297727 cites W1986730363 @default.
- W1888297727 cites W1988306770 @default.
- W1888297727 cites W1988875152 @default.
- W1888297727 cites W1989788017 @default.
- W1888297727 cites W2000385883 @default.
- W1888297727 cites W2014571977 @default.
- W1888297727 cites W2024172421 @default.
- W1888297727 cites W2025497764 @default.
- W1888297727 cites W2029579644 @default.
- W1888297727 cites W2032236554 @default.
- W1888297727 cites W2034252391 @default.
- W1888297727 cites W2034697240 @default.
- W1888297727 cites W2042684354 @default.
- W1888297727 cites W2056986228 @default.
- W1888297727 cites W2060668364 @default.
- W1888297727 cites W2062269069 @default.
- W1888297727 cites W2065404447 @default.
- W1888297727 cites W2069103813 @default.
- W1888297727 cites W2071416057 @default.
- W1888297727 cites W2077706229 @default.
- W1888297727 cites W2089392802 @default.
- W1888297727 cites W2095050229 @default.
- W1888297727 cites W2105051934 @default.
- W1888297727 cites W2117118271 @default.
- W1888297727 cites W2118438547 @default.
- W1888297727 cites W2122441020 @default.
- W1888297727 cites W2125678927 @default.
- W1888297727 cites W2127305172 @default.
- W1888297727 cites W2128643129 @default.
- W1888297727 cites W2130369250 @default.
- W1888297727 cites W2131233378 @default.
- W1888297727 cites W2132474153 @default.
- W1888297727 cites W2148051437 @default.
- W1888297727 cites W2150926871 @default.
- W1888297727 cites W2156709395 @default.
- W1888297727 cites W2169601053 @default.
- W1888297727 cites W2239810529 @default.
- W1888297727 cites W2308684299 @default.
- W1888297727 cites W2411240981 @default.
- W1888297727 cites W4241827759 @default.
- W1888297727 cites W4243952877 @default.
- W1888297727 cites W4253664160 @default.
- W1888297727 doi "https://doi.org/10.1093/genetics/148.1.59" @default.
- W1888297727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1459773" @default.
- W1888297727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9475721" @default.
- W1888297727 hasPublicationYear "1998" @default.
- W1888297727 type Work @default.
- W1888297727 sameAs 1888297727 @default.
- W1888297727 citedByCount "31" @default.
- W1888297727 countsByYear W18882977272016 @default.
- W1888297727 countsByYear W18882977272017 @default.
- W1888297727 crossrefType "journal-article" @default.
- W1888297727 hasAuthorship W1888297727A5046719549 @default.
- W1888297727 hasAuthorship W1888297727A5054332041 @default.
- W1888297727 hasBestOaLocation W18882977271 @default.
- W1888297727 hasConcept C104317684 @default.
- W1888297727 hasConcept C112212490 @default.
- W1888297727 hasConcept C134494468 @default.
- W1888297727 hasConcept C134935766 @default.
- W1888297727 hasConcept C180754005 @default.
- W1888297727 hasConcept C2777271071 @default.
- W1888297727 hasConcept C2777576037 @default.
- W1888297727 hasConcept C29906990 @default.
- W1888297727 hasConcept C501734568 @default.
- W1888297727 hasConcept C54355233 @default.
- W1888297727 hasConcept C60748783 @default.
- W1888297727 hasConcept C86803240 @default.
- W1888297727 hasConceptScore W1888297727C104317684 @default.
- W1888297727 hasConceptScore W1888297727C112212490 @default.
- W1888297727 hasConceptScore W1888297727C134494468 @default.
- W1888297727 hasConceptScore W1888297727C134935766 @default.
- W1888297727 hasConceptScore W1888297727C180754005 @default.