FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888490882> ?p ?o ?g. }

• W1888490882 endingPage "413" @default.
• W1888490882 startingPage "405" @default.
• W1888490882 abstract "A new basic protein, designated ligatoxin B, containing 46 amino acid residues has been isolated from the mistletoe Phoradendron liga (Gill.) Eichl. (Viscaceae). The protein's primary structure, determined unambiguously using a combination of automated Edman degradation, trypsin enzymic digestion, and tandem MS analysis, was 1-KSCCPSTTAR-NIYNTCRLTG-ASRSVCASLS-GCKIISGSTC-DSGWNH-46. Ligatoxin B exhibited in vitro cytotoxic activities on the human lymphoma cell line U-937-GTB and the primary multidrug-resistant renal adenocarcinoma cell line ACHN, with IC50 values of 1.8 microM and 3.2 microM respectively. Sequence alignment with other thionins identified a new member of the class 3 thionins, ligatoxin B, which is similar to the earlier described ligatoxin A. As predicted by the method of homology modelling, ligatoxin B shares a three-dimensional structure with the viscotoxins and purothionins and so may have the same mode of cytotoxic action. The novel similarities observed by structural comparison of the helix-turn-helix (HTH) motifs of the thionins, including ligatoxin B, and the HTH DNA-binding proteins, led us to propose the working hypothesis that thionins represent a new group of DNA-binding proteins. This working hypothesis could be useful in further dissecting the molecular mechanisms of thionin cytotoxicity and of thionin opposition to multidrug resistance, and useful in clarifying the physiological function of thionins in plants." @default.
• W1888490882 created "2016-06-24" @default.
• W1888490882 creator A5013774251 @default.
• W1888490882 creator A5019814143 @default.
• W1888490882 creator A5020881873 @default.
• W1888490882 creator A5028160249 @default.
• W1888490882 creator A5032895588 @default.
• W1888490882 creator A5048990620 @default.
• W1888490882 creator A5074895961 @default.
• W1888490882 creator A5091281244 @default.
• W1888490882 date "2002-09-01" @default.
• W1888490882 modified "2023-10-18" @default.
• W1888490882 title "Ligatoxin B, a new cytotoxic protein with a novel helix–turn–helix DNA-binding domain from the mistletoe Phoradendron liga" @default.
• W1888490882 cites W1495926848 @default.
• W1888490882 cites W1505612226 @default.
• W1888490882 cites W1512797429 @default.
• W1888490882 cites W1555187143 @default.
• W1888490882 cites W1656708631 @default.
• W1888490882 cites W174651672 @default.
• W1888490882 cites W1964767673 @default.
• W1888490882 cites W1966809971 @default.
• W1888490882 cites W1978607217 @default.
• W1888490882 cites W1978811081 @default.
• W1888490882 cites W1992919625 @default.
• W1888490882 cites W1996307860 @default.
• W1888490882 cites W1998158297 @default.
• W1888490882 cites W2003633686 @default.
• W1888490882 cites W2003695026 @default.
• W1888490882 cites W2005120335 @default.
• W1888490882 cites W2008139062 @default.
• W1888490882 cites W2026258231 @default.
• W1888490882 cites W2036259941 @default.
• W1888490882 cites W2053991428 @default.
• W1888490882 cites W2057362316 @default.
• W1888490882 cites W2062377895 @default.
• W1888490882 cites W2065491156 @default.
• W1888490882 cites W2073299679 @default.
• W1888490882 cites W2080513007 @default.
• W1888490882 cites W2081592733 @default.
• W1888490882 cites W2084112626 @default.
• W1888490882 cites W2085301972 @default.
• W1888490882 cites W2092930692 @default.
• W1888490882 cites W2106882534 @default.
• W1888490882 cites W2120706631 @default.
• W1888490882 cites W2128623193 @default.
• W1888490882 cites W2130479394 @default.
• W1888490882 cites W2133335149 @default.
• W1888490882 cites W2137154596 @default.
• W1888490882 cites W2143534385 @default.
• W1888490882 cites W2149912493 @default.
• W1888490882 cites W2157316252 @default.
• W1888490882 cites W2170471837 @default.
• W1888490882 cites W2326845230 @default.
• W1888490882 cites W2379850224 @default.
• W1888490882 cites W2395894934 @default.
• W1888490882 cites W2396855485 @default.
• W1888490882 cites W2400673871 @default.
• W1888490882 cites W2403905043 @default.
• W1888490882 cites W2409851798 @default.
• W1888490882 cites W2418272901 @default.
• W1888490882 cites W2444618974 @default.
• W1888490882 cites W63069702 @default.
• W1888490882 doi "https://doi.org/10.1042/bj20020221" @default.
• W1888490882 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1222806" @default.
• W1888490882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12049612" @default.
• W1888490882 hasPublicationYear "2002" @default.
• W1888490882 type Work @default.
• W1888490882 sameAs 1888490882 @default.
• W1888490882 citedByCount "43" @default.
• W1888490882 countsByYear W18884908822012 @default.
• W1888490882 countsByYear W18884908822013 @default.
• W1888490882 countsByYear W18884908822014 @default.
• W1888490882 countsByYear W18884908822015 @default.
• W1888490882 countsByYear W18884908822016 @default.
• W1888490882 countsByYear W18884908822017 @default.
• W1888490882 countsByYear W18884908822018 @default.
• W1888490882 countsByYear W18884908822019 @default.
• W1888490882 countsByYear W18884908822020 @default.
• W1888490882 countsByYear W18884908822021 @default.
• W1888490882 countsByYear W18884908822022 @default.
• W1888490882 countsByYear W18884908822023 @default.
• W1888490882 crossrefType "journal-article" @default.
• W1888490882 hasAuthorship W1888490882A5013774251 @default.
• W1888490882 hasAuthorship W1888490882A5019814143 @default.
• W1888490882 hasAuthorship W1888490882A5020881873 @default.
• W1888490882 hasAuthorship W1888490882A5028160249 @default.
• W1888490882 hasAuthorship W1888490882A5032895588 @default.
• W1888490882 hasAuthorship W1888490882A5048990620 @default.
• W1888490882 hasAuthorship W1888490882A5074895961 @default.
• W1888490882 hasAuthorship W1888490882A5091281244 @default.
• W1888490882 hasBestOaLocation W18884908822 @default.
• W1888490882 hasConcept C104317684 @default.
• W1888490882 hasConcept C153911025 @default.
• W1888490882 hasConcept C167625842 @default.
• W1888490882 hasConcept C552990157 @default.
• W1888490882 hasConcept C55493867 @default.
• W1888490882 hasConcept C86803240 @default.
• W1888490882 hasConcept C87933860 @default.

• next